Cardiac lymph flow and composition in acute myocardial ischemia in dogs.
Cardiac lymph flow and composition in acute myocardial ischemia in dogs.
复制标题
狗急性心肌缺血时的心脏淋巴液流动和成分。
作者：
M. Feola;G. Glick
从12只正常犬（第1组）连续两个2小时的对照期和7只犬（第2组）的左冠状动脉回旋支分支闭塞前2小时和闭塞后2小时获得心脏淋巴液。淋巴组成进行了研究，参考pH值，红细胞（RBC）浓度，总蛋白含量，钾和钠离子浓度，肌酸磷酸激酶（CPK）和酸性磷酸酶的酶活性。在前2小时内，两组之间的任何变量均无显著差异。在第1组中，任何变量均未因时间推移而发生显著变化。在第2组中，心肌缺血2小时，淋巴流量增加53.3 ± 5.1%，蛋白质含量增加67 ± 5%，红细胞浓度增加418 ± 27%，表明毛细血管通透性增加。乳酸升高120.5 ± 27%，钾浓度升高16.9 ± 2.4%，酸性磷酸酶升高30 ± 3%，CPK升高61.6 ± 10.9%，提示心肌细胞缺血性损伤。淋巴液中的这些变化具有统计学显著性（P <0.05），反映了毛细血管和心肌细胞的异常。
Cardiac lymph was obtained from 12 normal dogs (group 1) for two consecutive 2-h control periods and from 7 dogs (group 2) for 2 h before and 2 h after occlusion of the circumflex branch of the left coronary artery. Lymph composition was studied with reference to pH, red blood cell (RBC) concentration, total protein content, potassium and sodium ion concentrations, and creatine phosphokinase (CPK) and acid phosphatase enzyme activities. No significant difference was noted in any variable between the two groups during the firts 2-h period. In group 1, no significant changes occurred in any variable as a result of the passage of time alone. In group 2, 2 h of myocardial ischemia produced increases of 53.3 plus or minus 5.1% in lymph flow, 67 plus or minus 5% in protein content, and 418 plus or minus 27% in the RBC concentration, suggesting increased blood capillary permeability. Lactate rose 120.5 plus or minus 27%, potassium concentration increased 16.9 plus or minus 2.4%, acid phosphatase increased 30 plus or minus 3%, and CPK rose 61.6 pluse or minus 10.9%, suggesting ischemic injury of myocardial cells. These changes in lymph were statistically significant (P LESS THAN 0.05) and reflect both capillary and myocardial cell abnormalities.