The challenge of the lantibiotics: synthetic approaches to thioether-bridged peptides
The challenge of the lantibiotics: synthetic approaches to thioether-bridged peptides
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DOI：
10.1039/c1ob05946g
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发表时间：
2011-01-01
影响因子：
3.2
通讯作者：
Tabor, Alethea B.
中科院分区：
文献类型：
--
作者：
Tabor, Alethea B.
羊毛硫抗生素独特的抗菌特性和结构复杂性激发了人们对开发合成这些肽的方法的极大兴趣。最具挑战性的问题之一是侧链之间具有多个硫醚桥的多环肽的合成，这是羊毛硫抗生素的特征。从这个角度来看，我们回顾了解决这个问题的不同方法，包括溶液相合成、固相合成、仿生方法和生物转化策略，强调了每种方法所取得的进展。
The unique antibacterial properties and structural complexity of the lantibiotics has stimulated considerable interest in the development of methodology to synthesise these peptides. One of the most challenging issues has been the synthesis of polycyclic peptides with multiple thioether bridges between side-chains, which are a characteristic feature of the lantibiotics. In this perspective, the different approaches to this problem, including solution-phase synthesis, solid-phase synthesis, biomimetic approaches and biotransformation strategies, are reviewed, highlighting the advances resulting from each of these approaches.