Potential Antiviral Lignans from the Roots of Saururus chinensis with Activity against Epstein-Barr Virus Lytic Replication
Potential Antiviral Lignans from the Roots of Saururus chinensis with Activity against Epstein-Barr Virus Lytic Replication
复制标题
来自三白草根部的潜在抗病毒木酚素，具有抗 Epstein-Barr 病毒裂解复制的活性。
DOI：
10.1021/np400757k
复制
发表时间：
2014-01-01
影响因子：
5.1
通讯作者：
Gu, Qiong
中科院分区：
文献类型：
--
作者：
Cui, Hui;Xu, Bo;Gu, Qiong
Epstein-Barr virus (EBV) is a member of the γ-herpes virus subfamily and has been implicated in the pathogenesis of several human malignancies. Bioassay-guided fractionation was conducted on an EtOAc-soluble extract of the roots of Saururus chinensis and monitored using an EBV lytic replication assay. This led to the isolation of 19 new (1-19) and nine known (20-28) lignans. The absolute configurations of the new lignans were established by Mosher's ester, ECD, and computational methods. Eight lignans, including three sesquineolignans (19, 23, and 24) and five dineolignans (3, 4, 26, 27, and 28), exhibited inhibitory effects toward EBV lytic replication with EC50 values from 1.09 to 7.55 μM and SI values from 3.3 to 116.4. In particular, manassantin B (27) exhibited the most promising inhibition, with an EC50 of 1.72 μM, low cytotoxicity, CC50 > 200 μM, and SI > 116.4. This is the first study demonstrating that lignans possess anti-EBV lytic replication activity.
