ATRIAL NATRIURETIC PEPTIDE IN HUMAN-URINE
ATRIAL NATRIURETIC PEPTIDE IN HUMAN-URINE
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DOI：
10.1007/bf01726575
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发表时间：
1988-09-01
期刊：
影响因子：
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通讯作者：
MARUMO, F
中科院分区：
文献类型：
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作者：
ANDO, K;UMETANI, N;MARUMO, F
建立了一种测量尿液中心房钠尿肽（ANP）浓度的高灵敏度放射免疫测定法，并展示了其临床用途。尿液中ANP稳定在4°C。 C 持续数天，并且可以通过我们的放射免疫测定法轻松测量。 65 名健康人的平均 ANP 排泄量为 25.0 .+-。 1.4 ng/天（平均值.+-.SEM），ANP 的排泄分数为 0.7.+-。 0.05%。在 14 名充血性心力衰竭患者中，平均 ANP 排泄量为 119.2 +/-。 29.4 纳克/天，下降至 53.3 .+-。治疗成功后11.0。
A highly sensitive radioimmunoassay to measure atrial natriuretic peptide (ANP) concentration in urine has been established, and its clinical usefulness is presented. ANP in urine was stable at 4.degree. C for several days and was easily measured by our radioimmunoassay. The average ANP excretion in 65 healthy persons was 25.0 .+-. 1.4 ng/day (mean .+-. SEM) and the fractional excretion of ANP was 0.7 .+-. 0.05%. In 14 patients with congestive heart failure, the average ANP excretion was 119.2 .+-. 29.4 ng/day, which decreased to 53.3 .+-. 11.0 after successful treatment.