Dyspnoea and comorbidity contribute to anxiety and depression in interstitial lung disease
Dyspnoea and comorbidity contribute to anxiety and depression in interstitial lung disease
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DOI：
10.1111/resp.12360
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发表时间：
2014-11-01
期刊：
影响因子：
6.9
通讯作者：
Glaspole, Ian
中科院分区：
文献类型：
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作者：
Holland, Anne E.;Fiore, Julio F., Jr.;Glaspole, Ian
背景和目的间质性肺病(ILD)中焦虑的流行情况知之甚少，导致抑郁的因素也不清楚。本研究旨在探讨ILD患者中焦虑和抑郁的患病率及其预测因素。方法选择124例ILD患者(年龄：，标准差12岁，48例特发性肺纤维化)。使用医院焦虑和抑郁量表评估焦虑和抑郁，以确定可能的病例和边缘病例。研究对象包括人口学资料、呼吸功能、步行6分钟和改良医学研究理事会呼吸困难评定量表(MMRC)。23%的人存在抑郁，其中7%的人有临床上显著的抑郁。焦虑的独立预测因素是步行时MMRC评分较高(P=0.005，OR=2.60，95%可信区间为1.37~4.92)和较低SPO(2)(P=0.003，OR为1.16，1.04~1.30)。抑郁的独立预测因素有较高的MMRC评分(P=0.006，病例OR3.84，1.2 5~11.78，临界病例OR2.44，1.14~5.19)和较多的并发症(P=0.003，病例OR2.0 2，0.97~4.2 1，临界病例OR2.2 6，1.3 0~3.93)。呼吸困难和合并症是可接受干预的重要因素。我们评估了ILD患者焦虑的患病率和抑郁的致病因素。在相当少数的个体中，焦虑和抑郁是共存的。功能性呼吸困难和较多的合并症导致抑郁。
Background and objectivesLittle is known about the prevalence of anxiety in interstitial lung disease (ILD), and the contributors to depression are not clear. The aim of this study was to determine the prevalence and predictors of anxiety and depression in people with ILD.MethodsOne hundred and twenty-four individuals with ILD (age 64 years (standard deviation 12), 48 idiopathic pulmonary fibrosis) participated. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale to determine likely cases and borderline cases. Associations with demographic data, respiratory function, 6-min walk and Modified Medical Research Council Dyspnoea Scale (MMRC) were examined.ResultsThe prevalence of anxiety was 31%, with clinically significant anxiety in 12%. Depression was present in 23% of individuals, with 7% having clinically significant depression. Independent predictors of anxiety were a higher MMRC score (P=0.005, odds ratio (OR) for case 2.60, 95% confidence interval 1.37 to 4.92) and higher nadir SpO(2) during walking (P=0.003, OR for case 1.16, 1.04-1.30). Independent predictors of depression were a higher MMRC score (P=0.006, case OR 3.84, 1.25-11.78, borderline case OR 2.44, 1.14-5.19) and a greater number of comorbidities (P=0.003, case OR 2.02, 0.97-4.21, borderline case OR 2.26, 1.30-3.93).ConclusionsAnxiety and depression are present in a significant minority of individuals with ILD. Dyspnoea and comorbidities are important contributors that may be amenable to intervention.The prevalence of anxiety and the contributing factors to depression in ILD were evaluated. Anxiety and depression were comorbidities in a significant minority of individuals. Functional dyspnoea and a higher number of comorbidities contributed to depression.