Progression of understanding for the role of Epstein-Barr virus and management of nasopharyngeal carcinoma.
Progression of understanding for the role of Epstein-Barr virus and management of nasopharyngeal carcinoma.
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DOI：
10.1007/s10555-017-9693-x
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发表时间：
2017-09
期刊：
影响因子：
--
通讯作者：
Yoshizaki T
中科院分区：
文献类型：
--
作者：
Nakanishi Y;Wakisaka N;Kondo S;Endo K;Sugimoto H;Hatano M;Ueno T;Ishikawa K;Yoshizaki T
鼻咽癌（Nasopharyngeal carcinoma，NPC）是我国南方及东南亚地区的常见病。在NPC流行的地区，未分化亚型构成大多数病例，并且总是与EB病毒（EBV）感染相关，而分化亚型在世界其他地区更常见。未分化型鼻咽癌在流行病学、病因学和临床表现方面是一种独特的恶性肿瘤。鼻咽癌具有高度侵袭性和转移性，对化疗和放疗敏感。在过去的三十年里，由于管理方面的进步，包括RT技术的改进，化疗的更广泛应用以及更准确的疾病分期，总体预后得到了显着改善。尽管现代RT具有出色的本地控制，但远程故障仍然是一个具有挑战性的问题。分子生物学技术的发展有助于阐明鼻咽癌的分子发病机制。本文就EB病毒基因产物在鼻咽癌发病中的作用及鼻咽癌的治疗现状作一综述。
Nasopharyngeal carcinoma (NPC) is very common in southern China and Southeast Asia. In regions where NPC is endemic, undifferentiated subtypes constitute most cases and are invariably associated with Epstein-Barr virus (EBV) infection, whereas the differentiated subtype is more common in other parts of the world. Undifferentiated NPC is a unique malignancy with regard to its epidemiology, etiology, and clinical presentation. Clinically, NPC is highly invasive and metastatic, but sensitive to both chemotherapy and radiotherapy (RT). Overall prognosis has dramatically improved over the past three decades because of advances in management, including the improvement of RT technology, the broader application of chemotherapy, and more accurate disease staging. Despite the excellent local control with modern RT, distant failure remains a challenging problem. Advances in molecular technology have helped to elucidate the molecular pathogenesis of NPC. This article reviews the contribution of EBV gene products to NPC pathogenesis and the current management of NPC.
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影响因子：
3.4
作者：
Demaria S;Pilones KA;Vanpouille-Box C;Golden EB;Formenti SC
通讯作者：
Formenti SC
影响因子：
50.5
作者：
Fountzilas, G.;Ciuleanu, E.;Ciuleanu, T.
通讯作者：
Ciuleanu, T.
影响因子：
51.1
作者：
Chen, Lei;Hu, Chao-Su;Ma, Jun
通讯作者：
Ma, Jun
影响因子：
6.4
作者：
Cheng, JCH;Chao, KSC;Low, D
通讯作者：
Low, D
DOI：
10.1158/1078-0432.ccr-13-0855
发表时间：
2013-07-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Chen BJ;Chapuy B;Ouyang J;Sun HH;Roemer MG;Xu ML;Yu H;Fletcher CD;Freeman GJ;Shipp MA;Rodig SJ
通讯作者：
Rodig SJ