A detailed analysis of rats' spatial memory in a probe trial of a Morris task
A detailed analysis of rats' spatial memory in a probe trial of a Morris task
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DOI：
10.1016/j.bbr.2004.01.022
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发表时间：
2004-09-23
影响因子：
2.7
通讯作者：
Been, M
中科院分区：
文献类型：
--
作者：
Blokland, A;Geraerts, E;Been, M
在本研究中，我们评估了大鼠在Morris水中逃逸任务的探测试验中的搜索行为。更具体地说，考察了在不同区域进行的2min探头试验的不同阶段的空间记忆。大鼠每天进行4次训练，训练4天后，在第一次探测试验中测试它们的空间记忆。在四个30-S间隔期间，大鼠表现出对目标象限的偏爱。在S的四个30岁的间隔中，环上的时间都减少了。在第二次探测试验中也观察到了对前一个目标象限的偏好，当时大鼠接受了4天的额外训练，每天进行4次试验。然而，在探头试验的前30-S期间，在环上花费的时间最长，在接下来的3个30-S间隔期间，在环状结构中花费的时间较少且相似。因此，60只S的探测试验似乎低估了大鼠的空间能力。看来，使用象限来评估表现可能会高估老鼠的空间能力。我们的发现表明，在Morris水逃生任务中对大鼠的空间记忆进行探测试验的评估需要更详细的分析。(C)2004爱思唯尔B.V.保留所有权利。
In the present study, we evaluated the search behavior of rats during a probe trial of a Morris water escape task. More specifically, the spatial memory during different stages of a 2 min probe trial in different zones was examined. After rats were trained for 4 days with four trials per day, their spatial memory was tested in a first probe trial. The rats showed a preference for the target quadrant during each of four 30-s intervals. The time in the annulus decreased across the four 30-s intervals. The preference for the previous target quadrant was also observed in a second probe trial, when the rats had received additional training for 4 days with four trials per day. However, the time spent in the annulus was highest during the first 30-s of the probe trial, and was lower and similar during the next three 30-s intervals. Therefore, probe trials of 60 s seem to underestimate the spatial ability of rats. It appears that using a quadrant for assessing the performance may overestimate the spatial ability of a rat. Our findings suggest that the evaluation of the spatial memory of rats in a probe trial in the Morris water escape task requires a more detailed analysis. (C) 2004 Elsevier B.V. All rights reserved.