The effect of fear of falling on prefrontal cortex activation and efficiency during walking in older adults
The effect of fear of falling on prefrontal cortex activation and efficiency during walking in older adults
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DOI：
10.1007/s11357-019-00056-4
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发表时间：
2019-02-01
期刊：
影响因子：
5.6
通讯作者：
Ye, Kenny
中科院分区：
文献类型：
--
作者：
Holtzer, Roee;Kraut, Rebecca;Ye, Kenny
当较高的大脑激活与类似或更差的表现相关联时，可以推断出神经效率低下。当练习后与任务相关的大脑激活减少时，神经效率就会提高。没有关于跌倒恐惧（FOF）对步行过程中大脑激活的影响的信息。我们假设FOF的存在与神经效率低下有关，并且在双任务步行过程中神经效率的提高会延迟。任务条件包括单任务步行（STW），阿尔法（认知干扰）和双任务步行（DTW）。功能性近红外光谱（fNIRS）-前额叶皮层（PFC）中的HbO（2）被用来量化大脑激活中与任务相关的变化。练习包括三个重复的平衡试验，每个任务。包括FOF受试者（n=19;平均年龄=79.84 +/-6.01岁;女性%=68.42）和无FOF受试者（n=56;平均年龄=76.73 +/-6.39岁;女性%=44.64）。FOF的存在与较慢的步速（估计值=-12.354; p= 0.0154）以及从STW到DTW（估计值=0.303，p=0.0009）和从Alpha到DTW（估计值=0.387，p
Neural inefficiency is inferred when higher brain activations are associated with similar or worse performance. Improved neural efficiency is achieved when task-related brain activations are reduced after practice. No information is available on the effect of fear-of-falling (FOF) on brain activation during walking. We hypothesized that the presence of FOF would be associated with neural inefficiency and with a delay in improving neural efficiency during dual-task walking. Task conditions included single-task walk (STW), Alpha (cognitive interference), and dual-task walk (DTW). Functional near-infrared spectroscopy (fNIRS)-derived HbO(2) in the prefrontal cortex (PFC) was used to quantify task-related changes in brain activation. Practice included three repeated counterbalanced trials for each task. Participants with FOF (n=19; mean age =79.84 +/- 6.01years; %female =68.42) and without FOF (n=56; mean age =76.73 +/- 6.39years; %female =44.64) were included. The presence of FOF was associated with slower stride velocity (estimate =-12.354; p= 0.0154) and with greater increases in PFC HbO(2) from STW to DTW (estimate =0.303, p=0.0009) and from Alpha to DTW (estimate =0.387, p