EARLY ASPECTS OF LOCOWEED TOXICOSIS AND EVALUATION OF A MINERAL SUPPLEMENT OR CLINOPTILOLITE AS DIETARY TREATMENTS
EARLY ASPECTS OF LOCOWEED TOXICOSIS AND EVALUATION OF A MINERAL SUPPLEMENT OR CLINOPTILOLITE AS DIETARY TREATMENTS
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DOI：
10.2527/1992.70103125x
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发表时间：
1992-10-01
影响因子：
3.3
通讯作者：
GRAHAM, JD
中科院分区：
文献类型：
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作者：
BACHMAN, SE;GALYEAN, ML;GRAHAM, JD
16个杂交肉牛被用来确定血清临床特征的诊断工具，用于检测疯草毒性的早期阶段，并测试两种矿物质补充剂的预防或治疗中毒的能力。饮食处理是（DM基础）1）100%高粱苏丹草干草，2）80%高粱苏丹草干草：20%疯草，3）80%高粱苏丹草干草：20%疯草加100 g Silent Herder矿物质混合物（据报道减轻疯草毒性的矿物质补充剂），和4）80%高粱苏丹草干草：20%疯草加100 g斜发沸石（天然沸石粘土）。日粮饲喂1.5%的BW为28天，之后，小母牛有自由进入高粱苏丹草干草为14天。颈静脉血采样喂养前每7天，并在2，4，6，和8 h喂养后的第28天。与对照组相比，饲喂疯草的小母牛从第7天到第35天血清碱性磷酸酶活性升高（P <0.01）。在第42天，碱性磷酸酶活性的小母牛先前喂疯草低于（P <0.05）比对照小母牛。血清谷草转氨酶活性升高（P <0.01）的小母牛喂疯草从d 7至42与对照小母牛相比。在饲喂疯草的小母牛中，血清铁浓度在第7天至第28天较低（P <0.01），但没有观察到治疗效应（P > 0.05）。10)在D 35或42。在第28天，血清生长激素、催乳素和褪黑激素浓度无差异（P > 0.05）。10），但胰岛素在饲喂Silent Herder和斜发沸石的小母牛中低于仅饲喂疯草的小母牛（P <0.05）。饮食中含有20%疯草改变了血清中的碱性磷酸酶，谷草转氨酶，铁，这些血清成分可能作为疯草中毒的早期阶段的指标。无论是沉默的牧人，也斜发沸石改善疯草的毒性作用。
Sixteen crossbred beef heifers were used to determine the efficacy of serum clinical profiles as diagnostic tools for detection of early stages of locoweed toxicity and to test the ability of two mineral supplements for prevention or therapy of toxicosis. Dietary treatments were (DM basis) 1) 100% sorghum sudangrass hay, 2) 80% sorghum sudangrass hay:20% locoweed, 3) 80% sorghum sudangrass hay:20% locoweed plus 100 g of Silent Herder Mineral Mix (a mineral supplement reported to alleviate locoweed toxicity), and 4) 80% sorghum sudangrass hay:20% locoweed plus 100 g of clinoptilolite (a natural zeolite clay). Diets were fed at 1.5% of BW for 28 d, after which heifers had ad libitum access to sorghum sudangrass hay for 14 d. Jugular blood was sampled before feeding every 7 d, and at 2, 4, 6, and 8 h after feeding on d 28. Compared with controls, heifers fed locoweed had elevated (P < .01) serum alkaline phosphatase activities from d 7 through 35. On d 42, alkaline phosphatase activities in heifers previously fed locoweed were lower (P < .05) than in control heifers. Serum glutamic oxaloacetic transaminase activities were elevated (P < .01) in heifers fed locoweed from d 7 through 42 compared with control heifers. In heifers fed locoweed, serum Fe concentrations were less (P < .01) on d 7 through 28, but no treatment effects were noted (P > . 10) on d 35 or 42. On d 28, serum somatotropin, prolactin, and melatonin concentrations did not differ (P > . 1 0) among treatments, but insulin was lower (P < .05) in heifers fed Silent Herder and clinoptilolite than in heifers fed only locoweed. Diets containing 20% locoweed altered the serum concentrations of alkaline phosphatase, glutamic oxaloacetic transaminase, and Fe; these serum constituents may serve as indices of early stages of locoweed toxicosis. Neither Silent Herder nor clinoptilolite ameliorated the toxic effects of locoweed.