Normal uptake of 18F-FDG in the testis:: an assessment by PET/CT
Normal uptake of 18F-FDG in the testis:: an assessment by PET/CT
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DOI：
10.1007/s12149-007-0041-z
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发表时间：
2007-09-01
影响因子：
2.6
通讯作者：
Sugitnura, Kazuro
中科院分区：
文献类型：
--
作者：
Kitajima, Kazuhiro;Nakarnoto, Yuji;Sugitnura, Kazuro
目的应用正电子发射断层扫描-计算机断层扫描（PET/CT）评价正常睾丸对f -18-氟-2-脱氧葡萄糖（FDG）的生理摄取及其与年龄、血糖水平和睾丸体积的关系。方法对203例男性进行PET/CT扫描，测量睾丸对F-18-FDG的摄食量，以标准化摄食量（SUV）表示。评估SUV与年龄、血糖水平、睾丸体积的相关性。结果406例睾丸的SUV值为2.44±0.45（范围1.23 ~ 3.85）。30-39岁（n = 12）、40-49岁（n = 64）、50-59岁（n = 82）、60-69岁（n = 86）、70-79岁（n = 86）、80-89岁（n = 76）的SUV分别为2.81 +/- 0.43（2.28-3.85）、2.63 +/- 0.45（1.77-3.75）、2.63 +/- 0.45（1.47 -3.29）、2.18 +/- 0.45（1.23-3.03）。当我们计算每位患者双侧睾丸的平均SUV时，使用Bonferroni校正的非配对检验，30-39岁与80-89岁、40-49岁与80-89岁、50-60岁与80-89岁之间的差异有统计学意义。203例男性侧侧指数（|L - R|/(L + R) x2）为0.066 +/- 0.067（0-0.522）。平均SUV与年龄（r=-0.284, P < 0.001）、平均SUV与平均体积（r= +0.368, P < 0.001）存在轻度相关。平均SUV与血糖水平无相关性（r=-0.065, P = 0.358）。结论正常睾丸有一定的FDG摄取，且随年龄的增长略有下降。睾丸中FDG的生理性摄取不应与病理性积累相混淆。
Objective The aim of this study was to assess the physiological uptake of F-18-fluoro-2-deoxyglucose (FDG) by an apparently normal testis with combined positron emission tomography-computed tomography (PET/CT) and its correlation with age, blood glucose level, and testicular volume.Methods The testicular uptake of F-18-FDG, expressed as the standardized uptake value (SUV), was measured on PET/CT images in 203 men. The correlation between SUV and age, blood glucose level, and testicular volume was assessed.Results The SUV in the total of 406 testes was 2.44 +/- 0.45 (range 1.23-3.85). The SUV was 2.81 +/- 0.43 (2.28-3.85) for 30-39 years (n = 12), 2.63 +/- 0.45 (1.77-3.75) for 40-49 years (n = 64), 2.46 +/- 0.35 (1.44-3.15) for 50-59 years (n = 82), 2.51 +/- 0.41 (1.50-3.46) for 60-69 years (n = 86), 2.43 +/- 0.47 (1.42-3.29) for 70-79 years (n = 86), and 2.18 +/- 0.45 (1.23-3.03) for 80-89 years (n = 76). When we calculated the mean SUV of bilateral testes in each patient, there were significant statistical differences between those in the age group of 30-39 years and 80-89 years, 40-49 years and 80-89 years, and 50-60 years and 80-89 years, when using an unpaired test with Bonferroni correction. The laterality index (|L - R|/(L + R) x 2) in 203 men was 0.066 +/- 0.067 (0-0.522). There was a mild correlation between the mean SUV and age (r=-0.284, P < 0.001) as well as between the mean SUV and mean volume (r = +0.368, P < 0.001). There was no correlation between the mean SUV and glucose blood level (r=-0.065, P = 0.358).Conclusions Some uptake of FDG is observed in the normal testis and declines slightly with age. Physiological FDG uptake in the testis should not be confused with pathological accumulation.