The oxygen trail: tissue oxygenation
The oxygen trail: tissue oxygenation
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DOI：
10.1258/0007142991902312
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发表时间：
1999-01-01
影响因子：
6.7
通讯作者：
Singer, M
中科院分区：
文献类型：
--
作者：
Nathan, AT;Singer, M
有氧细胞呼吸依赖于氧和基质对线粒体的有效供应。从环境到亚细胞环境有一个氧气级联反应。有效的氧气输送取决于呼吸和循环系统之间的协调相互作用。大血管和微血管水平的循环都受体液和神经因素的控制。通过反映组织能量状态的代谢因子，在组织水平上存在局部血流自动调节。对缺氧的反应涉及细胞因子和遗传控制因子的激活，这些因子使毛细血管灌注和血红蛋白浓度最大化，并调节细胞代谢。在这样的条件下活性氧的形成对线粒体具有不利影响，具有呼吸链功能障碍、增加的渗透性转变和细胞死亡。这篇综述的目的是探索机制，通过它身体试图维持组织氧水平在细胞生存的最佳条件。
Aerobic cellular respiration depends on the efficient supply of oxygen and substrate to the mitochondria. There is an oxygen cascade from the environment to the subcellular environment. Efficient oxygen delivery depends on the coordinated interaction between the respiratory and circulatory systems. The circulation at both macro- and microvascular levels is under the control of humoral and neural factors. There is local autoregulation of flow at the tissue level by metabolic factors which reflect the energy state of the tissues. The response to hypoxia involves the activation of cytokines and genetically controlled factors which maximise capillary perfusion and haemoglobin concentration, and regulate cell metabolism. The formation of reactive oxygen species under such conditions has a detrimental effect on the mitochondria with respiratory chain dysfunction, increased permeability transition, and cell death. This review aims to explore the mechanisms by which the body attempts to maintain tissue oxygen levels at conditions optimal for cell survival.