Moisturizing effects of topical nicotinamide on atopic dry skin
Moisturizing effects of topical nicotinamide on atopic dry skin
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DOI：
10.1111/j.1365-4632.2004.02375.x
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发表时间：
2005-03-01
影响因子：
3.6
通讯作者：
Mizoguchi, M
中科院分区：
文献类型：
--
作者：
Soma, Y;Kashima, M;Mizoguchi, M
某些保湿剂可以改善特应性皮炎的皮肤屏障功能。外用烟酰胺对特应性干燥皮肤的影响尚不清楚。我们检查了局部烟酰胺对特应性干燥皮肤的效果，并将结果与白色凡士林的效果进行了左右对比研究。方法入选了28例特应性皮炎患者，双侧前臂均出现对称性干燥皮肤病变，并指导在左前臂涂抹含2%烟酰胺的烟酰胺霜，右前臂涂抹白色凡士林，在4或8周的治疗期内每天两次。通过仪器设备测量经表皮水分损失和角质层水合作用。通过图像分析仪测定胶带剥离角质层脱落的量（脱屑指数）。结果烟酰胺显著降低经皮水分流失，但白色凡士林没有表现出任何显着的效果。烟酰胺和白色矿脂均增加角质层水合作用，但烟酰胺的效果明显优于白色矿脂。脱屑指数与角质层水化在基线和逐渐增加，在烟酰胺组，但不是在白色petrolatumgroup.Conclusions烟酰胺霜是一种更有效的保湿比白色petrolatum对特应性干燥皮肤，并可作为一种治疗辅助特应性皮炎。
Background Certain moisturizers can improve skin barrier function in atopic dermatitis. The effect of topical nicotinamide on atopic dry skin is unknown. We examined the effect of topical nicotinamide on atopic dry skin and compared the results with the effect of white petrolatum in a left-right comparison study.Methods Twenty-eight patients with atopic dermatitis, with symmetrical lesions of dry skin on both forearms, were enrolled, and were instructed to apply nicotinamide cream containing 2% nicotinamide on the left forearm and white petrolatum on the right forearm, twice daily over a 4- or 8-week treatment period. Transepidermal water loss and stratum corneum hydration were measured by instrumental devices. The amount of the stratum corneum exfoliated by tape stripping (desquamation index) was determined by an image analyzer.Results Nicotinamide significantly decreased transepidermal water loss, but white petrolatum did not show any significant effect. Both nicotinamide and white petrolatum increased stratum corneum hydration, but nicotinamide was significantly more effective than white petrolatum. The desquamation index was positively correlated with stratum corneum hydration at baseline and gradually increased in the nicotinamide group, but not in the white petrolatum group.Conclusions Nicotinamide cream is a more effective moisturizer than white petrolatum on atopic dry skin, and may be used as a treatment adjunct in atopic dermatitis.