Prognostic and predictive value of epigenetic biomarkers and clinical factors in upper tract urothelial carcinoma
Prognostic and predictive value of epigenetic biomarkers and clinical factors in upper tract urothelial carcinoma
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表观遗传生物标志物和临床因素在上尿路尿路上皮癌的预后和预测价值。
DOI：
10.2217/epi.15.34
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发表时间：
2015-01-01
期刊：
影响因子：
3.8
通讯作者：
Zhou, Liqun
中科院分区：
文献类型：
--
作者：
Xiong, Gengyan;Liu, Jin;Zhou, Liqun
目的：我们进行了这项研究，以确定基因启动子甲基化状态和临床预测上尿路上皮癌（UTUC）患者。材料与方法：采用甲基化敏感PCR方法检测687例UTUC患者10个基因启动子区甲基化状态。结果如下：在本研究中证实了预测较高肿瘤分期（T3和T4）的三个基因的甲基化启动子、预测较高肿瘤分级（G3）的五个基因和预测pN+的一个基因。9个因素与癌症特异性生存率低显著相关。六个因素被认为是膀胱术后复发的预测因素。结论：甲基化通常发生在UTUC中，可能影响致癌机制，并且是UTUC中癌症特异性生存和膀胱复发的良好预测因素。
Aim: We conducted this study to identify gene promoter methylation status and clinical predictors for upper tract urothelial carcinoma (UTUC) patients. Materials & methods: Using methylation-sensitive PCR, we examined ten genes promoter methylation status in 687 UTUC patients. Results: A methylated promoter of three genes to predict higher tumor stage (T3 and T4), five genes to predict higher tumor grade (G3) and one gene to predict pN+ were certified in this study. Nine factors were significantly associated with poor cancer-specific survival. Six factors were considered as predictors to develop bladder recurrence after surgery. Conclusion: Methylation occurs commonly in UTUCs, may affect carcinogenic mechanisms, and is a well predictive factor for cancer-specific survival and bladder recurrence in UTUCs.