Syndromic obesity with neurodevelopmental delay: Opportunities for targeted interventions
Syndromic obesity with neurodevelopmental delay: Opportunities for targeted interventions
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DOI：
10.1016/j.ejmg.2022.104443
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发表时间：
2022-01-28
影响因子：
1.9
通讯作者：
Osundiji, Mayowa Azeez
中科院分区：
文献类型：
--
作者：
Kehinde, Tawakalitu Abosede;Bhatia, Alisha;Osundiji, Mayowa Azeez
在许多发达国家，肥胖是一个日益严重的公共卫生问题，尽管在一些发展中国家也有越来越多的类似趋势。肥胖的遗传基础继续引起越来越多的研究兴趣，调查和讨论。下一代测序技术的最新进展为肥胖的各种单基因和多基因原因提供了更多的线索。由于染色体或单基因缺陷引起的综合征性肥胖具有伴随的共病，其可包括神经发育迟缓、畸形以及器官特异性发育异常。对综合征性肥胖中神经发育挑战的性质的更好理解可能为个性化饮食和体力活动管理方法铺平道路。这篇综述文章描述了肥胖相关综合征的临床和分子遗传学方面以及相关的神经发育障碍。综合征性肥胖的个体化营养基因组管理的潜在机会也被强调。
Obesity is a growing public health problem in many developed countries, although similar trends are increasingly being described in some developing nations. The genetic underpinnings of obesity continue to arouse increasing research interests, investigations, and discussions. The recent advances in next generation sequencing technologies have shed some more light on the diverse monogenic and polygenic causes of obesity. Syndromic obesity due to chromosomal or monogenic defects has attendant co-morbidities, which may include neurodevelopmental delays, dysmorphism as well as organ-specific developmental anomalies. An improved understanding of the nature of neurodevelopmental challenges in syndromic obesity may pave the way for personalized dietary and physical activity management approaches. This review article describes the clinical and molecular genetic aspects of obesity-related syndromes and the associated neurodevelopmental disabilities. The potential opportunities for individualized nutrigenomic managements of syndromic obesity are also highlighted.