HELICOBACTER-PYLORI INFECTION AND CHRONIC GASTRITIS IN GASTRIC-CANCER
HELICOBACTER-PYLORI INFECTION AND CHRONIC GASTRITIS IN GASTRIC-CANCER
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DOI：
10.1136/jcp.45.4.319
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发表时间：
1992-04-01
影响因子：
3.4
通讯作者：
SEPPALA, K
中科院分区：
文献类型：
--
作者：
SIPPONEN, P;KOSUNEN, TU;SEPPALA, K
目的：了解幽门螺杆菌相关性慢性胃炎在胃癌患者中的流行情况。方法：对54例胃癌患者进行血清幽门螺杆菌抗体检测。对32例胃窦和胃体活检标本进行组织学检查(改良Giemsa法)，检测胃粘膜中幽门螺杆菌的感染率。结果：54例患者中，38例(70%)血清Hp抗体(Ig G)阳性(3例Hp抗体Ig A，类特异性，但不是Ig G特异性)。在35名对照组中，这一患病率显著高于(49%)(p<；0.05)。肠型(IGCA)和弥漫型(DGCA)胃癌患者Hp抗体阳性率差异无统计学意义，肠型(IGCA)和弥漫型(DGCA)患者Hp抗体阳性率均为71%。在32名受试者中，5名患者胃粘膜正常，4名患者表现为小体局限性萎缩(A型恶性贫血型萎缩)。这9例患者的血清(无抗体)或组织切片(Giemsa染色阴性)中均无Hp感染的证据。结论：在IGCA组和DGCA组中，75%的胃癌患者伴有Hp相关性慢性胃炎。大约25%的病例似乎有正常的胃或严重的体部局限性萎缩，这两种情况都没有伴随幽门螺杆菌感染的证据。
Aims: To investigate the prevalence of Helicobacter pylori associated chronic gastritis in patients with gastric cancer.Methods: Serum IgG antibodies for H pylori were determined in 54 consecutive patients with gastric carcinoma. The prevalence of H pylori in gastric mucosa was also examined histologically (modified Giemsa) in 32 patients from whom adequate biopsy specimens of the antrum and corpus were available. Thirty five patients with gastrointestinal tumours outside the stomach and 48 with non-gastrointestinal malignancies served as controls.Results: Of the 54 patients, 38 (70%) had H pylori antibodies (IgG) in their serum (three additional patients had H pylori antibodies IgA, class specific but not IgG specific). This prevalence was significantly higher (p < 0.05) than that (49%) in the 35 controls. No differences in prevalence of H pylori antibodies were found between gastric cancer cases of intestinal (IGCA) or diffuse (DGCA) type, both these types showing H pylori antibodies (IgG) in 71% of the patients. In the subgroup of 32 subjects, five patients had normal gastric mucosa and four showed corpus limited atrophy ("pernicious anaemia type" atrophy of type A). All of these nine patients had no evidence of current or previous H pylori infection in serum (no IgG antibodies) or in tissue sections (negative Giemsa staining). The remaining 23 patients had antral or pangastritis, and all had evidence of current or previous H pylori infection.Conclusions: H pylori associated chronic gastritis was the associated disease in 75% of the patients with gastric cancer occurring equally often in both IGCA and DGCA groups. About 25% of cases seem to have a normal stomach or severe corpus limited atrophy, neither of which showed evidence of concomitant H pylori infection.