Influence of lipids on protein-mediated transmembrane transport
Influence of lipids on protein-mediated transmembrane transport
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DOI：
10.1016/j.chemphyslip.2013.02.007
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发表时间：
2013-04-01
影响因子：
3.4
通讯作者：
Beckstein, Oliver
中科院分区：
文献类型：
--
作者：
Denning, Elizabeth J.;Beckstein, Oliver
跨膜蛋白负责在细胞膜的疏水区域运输离子和小分子。我们正在回顾通过与膜脂质的相互作用来调节这些运输过程的证据。我们专注于离子通道，包括钾通道，机械敏感和五聚体配体门控离子通道，以及活性转运体，包括泵，钠或质子驱动的二次转运体和ABC转运体。对于离子通道，已经有令人信服的证据表明，特定的脂质-蛋白相互作用可以直接影响它们的功能。在某些情况下，分子生物学和结构生物学结合计算机模拟的方法揭示了分子机制。还有许多转运蛋白的活性取决于脂质，但对其分子机制的了解才刚刚开始。2013爱思唯尔爱尔兰有限公司版权所有。
Transmembrane proteins are responsible for transporting ions and small molecules across the hydrophobic region of the cell membrane. We are reviewing the evidence for regulation of these transport processes by interactions with the lipids of the membrane. We focus on ion channels, including potassium channels, mechanosensitive and pentameric ligand gated ion channels, and active transporters, including pumps, sodium or proton driven secondary transporters and ABC transporters. For ion channels it has been convincingly shown that specific lipid-protein interactions can directly affect their function. In some cases, a combined approach of molecular and structural biology together with computer simulations has revealed the molecular mechanisms. There are also many transporters whose activity depends on lipids but understanding of the molecular mechanisms is only beginning. (C) 2013 Elsevier Ireland Ltd. All rights reserved.