Tolerizing allergic responses in the lung.
Tolerizing allergic responses in the lung.
复制标题
作者：
肺免疫系统的绝对要求是限制吸入的感染性病原体的炎症后果，同时保持对无害的空气过敏原的耐受性。这种耐受性是通过与肺基质细胞相互作用的细胞和分子的复杂网络来维持的。然而，在某些个体中，对诸如花粉、动物皮屑或灰尘的颗粒的耐受性发生了破坏，导致过敏性病理学的发展。新出现的证据表明，这种耐受性的下降受到个体遗传背景以及环境因素（如早期暴露于呼吸道病原体）的影响。进一步了解肺免疫系统维持耐受性的机制可能会导致开发新的治疗途径来治疗越来越多的慢性哮喘患者。
The absolute requirement of the pulmonary immune system is to limit the inflammatory consequences of inhaled infectious agents while maintaining tolerance to harmless aeroallergens. This tolerance is maintained by a complex network of cells and molecules interacting with lung stromal cells. However, in some individuals there is a breakdown in tolerance to particles such as pollens, animal dander, or dust, resulting in the development of allergic pathology. Emerging evidence suggests that this breakdown in tolerance is influenced by the genetic background of individuals as well as environmental considerations such as early exposure to respiratory pathogens. Further understanding of the mechanisms used by the pulmonary immune system to maintain tolerance might result in exploitation of novel avenues for therapy to treat the growing number of chronic asthmatic patients.
登录
查看更多内容
影响因子：
15.9
作者：
Bedoret, Denis;Wallemacq, Hugues;Bureau, Fabrice
通讯作者：
Bureau, Fabrice
影响因子：
158.5
作者：
Bisgaard, Hans;Hermansen, Mette Northman;Pipper, Christian Bressen
通讯作者：
Pipper, Christian Bressen
影响因子：
32.4
作者：
Barrett, Nora A.;Austen, K. Frank
通讯作者：
Austen, K. Frank
DOI：
10.1084/jem.20082901
发表时间：
2009-07-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Campbell JD;Buckland KF;McMillan SJ;Kearley J;Oldfield WL;Stern LJ;Grönlund H;van Hage M;Reynolds CJ;Boyton RJ;Cobbold SP;Kay AB;Altmann DM;Lloyd CM;Larché M
通讯作者：
Larché M
影响因子：
3.8
作者：
de Haar, C;Hassing, I;Pieters, R
通讯作者：
Pieters, R