Tumor-Infiltrating Natural Killer Cells.
Tumor-Infiltrating Natural Killer Cells.
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DOI：
10.1158/2159-8290.cd-20-0655
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发表时间：
2021-01
期刊：
影响因子：
28.2
通讯作者：
Vivier E
中科院分区：
文献类型：
--
作者：
Cózar B;Greppi M;Carpentier S;Narni-Mancinelli E;Chiossone L;Vivier E
由于其有效的抗肿瘤活性和促炎作用，自然杀伤（NK）细胞处于开发免疫肿瘤治疗的最前沿。NK细胞通过杀伤靶细胞和产生细胞因子参与对肿瘤的免疫应答。然而，在免疫抑制性肿瘤微环境中，NK细胞通过暴露于癌细胞产生的抑制分子而变得功能障碍，导致肿瘤逃逸。我们提供了一个概述，什么是已知的NK肿瘤的浸润和监视和机制，NK细胞变得功能失调。
Because of their potent antitumor activity and their proinflammatory role, natural killer (NK) cells are at the forefront of efforts to develop immuno-oncologic treatments. NK cells participate in immune responses to tumors by killing target cells and producing cytokines. However, in the immunosuppressive tumor microenvironment, NK cells become dysfunctional through exposure to inhibitory molecules produced by cancer cells, leading to tumor escape. We provide an overview of what is known about NK tumor in infiltration and surveillance and about the mechanisms by which NK cells become dysfunctional.