Solute diffusion through fibrotic tissue formed around protective cage system for implantable devices
Solute diffusion through fibrotic tissue formed around protective cage system for implantable devices
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DOI：
10.1002/jbm.b.33298
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发表时间：
2015-08-01
影响因子：
3.4
通讯作者：
Miki, Norihisa
中科院分区：
文献类型：
--
作者：
Prihandana, Gunawan Setia;Ito, Hikaru;Miki, Norihisa
本文提出了一种可植入笼系统的概念，该系统可以容纳和保护体内植入的生物医学传感和治疗装置。采用孔径为80 μ m的多孔聚乙烯醇（PVA）片和（或）开口为0.54 mm的不锈钢网制成的圆柱形笼，在大鼠背部皮下植入5周。对外植的笼子进行分析，发现笼子周围形成了纤维化组织。PVA网箱的纤维化组织主要沿着网箱的外表面生长，而不锈钢网箱的纤维化组织主要生长在网箱结构的内表面，这是由于不锈钢网箱的孔隙率较大。由于生物传感器检测具有短时间滞后的目标分子和具有低扩散阻力进出某些治疗装置的质量运输对于此类装置的成功至关重要，因此我们检查了笼周围形成的纤维组织是否对我们感兴趣的分子具有渗透性。为此，使用含有目标分子的溶液进行了浴池扩散和微流控室扩散实验。证实了钠、钾和尿素在纤维化组织中的扩散，从而表明这些被纤维化组织包围的圆柱形笼具有成功包裹植入式传感器和治疗装置的潜力。(c) 2014 Wiley期刊公司[J]中国生物医学工程学报，2016,31(3):555 - 557。
This article presents the concept of an implantable cage system that can house and protect implanted biomedical sensing and therapeutic devices in the body. Cylinder-shaped cages made of porous polyvinyl alcohol (PVA) sheets with an 80-mu m pore size and/or stainless steel meshes with 0.54-mm openings were implanted subcutaneously in the dorsal region of rats for 5 weeks. Analysis of the explanted cages showed the formation of fibrosis tissue around the cages. PVA cages had fibrotic tissue growing mostly along the outer surface of cages, while stainless steel cages had fibrotic tissue growing into the inside surface of the cage structure, due to the larger porosity of the stainless steel meshes. As the detection of target molecules with short time lags for biosensors and mass transport with low diffusion resistance into and out of certain therapeutic devices are critical for the success of such devices, we examined whether the fibrous tissue formed around the cages were permeable to molecules of our interest. For that purpose, bath diffusion and microfluidic chamber diffusion experiments using solutions containing the target molecules were performed. Diffusion of sodium, potassium and urea through the fibrosis tissue was confirmed, thus suggesting the potential of these cylindrical cages surrounded by fibrosis tissue to successfully encase implantable sensors and therapeutic apparatus. (c) 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 1180-1187, 2015.