BODY-SIZE AND FAT DISTRIBUTION AS PREDICTORS OF CORONARY HEART-DISEASE AMONG MIDDLE-AGED AND OLDER US MEN
BODY-SIZE AND FAT DISTRIBUTION AS PREDICTORS OF CORONARY HEART-DISEASE AMONG MIDDLE-AGED AND OLDER US MEN
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DOI：
10.1093/oxfordjournals.aje.a117385
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发表时间：
1995-06-15
影响因子：
5
通讯作者：
WILLETT, WC
中科院分区：
文献类型：
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作者：
RIMM, EB;STAMPFER, MJ;WILLETT, WC
在长期的前瞻性研究中，肥胖、男性脂肪分布和其他人体测量指标与冠心病相关，然而，由于年龄相关的激素变化和生活方式改变而导致的体重波动可能会在长期随访期间使相对风险估计产生偏差。作者在1986年对29,122名年龄在40-75岁之间的美国男性进行了一项S年前瞻性研究，前瞻性研究了体重指数（BMI）（kg/m2）、腰臀比和身高之间的关系，作为冠心病事件的独立预测因素。作者在随访期间记录了420例冠状动脉事件，体重指数、腰臀比、身材矮小和21岁以来体重增加与冠心病风险增加相关。在年龄小于65岁的男性中，校正其他冠状动脉危险因素后，相对危险度为1.72（95%置信区间（CI）1.10-2.69），BMI为25-28.9，2.61的男性对于BMI为29.0-32.9的肥胖男性，与BMI为33的瘦型男性相比，BMI为29.0-32.9的瘦型男性为3.44（95% CI 1.54-4.42），BMI ≥ 33的肥胖男性为3.44（95% CI 1.67-7.09）
Obesity, android fat distribution, and other anthropometric measures have been associated with coronary heart disease in long-term prospective studies, However, fluctuations in weight due to age-related hormonal changes and changes in lifestyle practices may bias relative risk estimates over a long follow-up period. The authors prospectively studied the association between body mass index (BMI) (kg/m(2)), waist-to-hip ratio, and height as independent predictors of incident coronary heart disease in a S-year prospective study among 29,122 US men aged 40-75 years in 1986. The authors documented 420 incident coronary events during the follow-up period, Body mass index, waist-to-hip ratio, short stature, and weight gain since age 21 were associated with an increased risk of coronary heart disease. Among men younger than 65, after adjusting for other coronary risk factors, the relative risk was 1.72 (95% confidence interval (Cl) 1.10-2.69)for men with BMI of 25-28.9, 2.61 (95% Cl 1.54-4.42) for BMI of 29.0-32.9, and 3.44 (95% Cl 1.67-7.09) for obese men with BMI greater than or equal to 33 compared with lean men with BMI