GLIAL SWELLING FOLLOWING HUMAN CEREBRAL CONTUSION - AN ULTRASTRUCTURAL-STUDY
GLIAL SWELLING FOLLOWING HUMAN CEREBRAL CONTUSION - AN ULTRASTRUCTURAL-STUDY
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DOI：
10.1136/jnnp.54.5.427
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发表时间：
1991-05-01
影响因子：
11
通讯作者：
ADAMS, JH
中科院分区：
文献类型：
--
作者：
BULLOCK, R;MAXWELL, WL;ADAMS, JH
本文对18例颅脑损伤病人手术后3 h ~ 11 d脑挫伤的超微结构进行了观察。 损伤后3小时至3天可见大量星形胶质细胞肿胀（“细胞毒性”水肿），在血管周围足突中最大，并压迫一些下层毛细血管。 紧密连接未被破坏。 神经元损伤在伤后3 ~ 11天最为明显。 导致水肿形成和神经元变性的病理生理机制进行了讨论。
The ultrastructural features of cerebral contusion seen three hours to 11 days after head injury were studied in 18 patients undergoing surgery. Massive astrocytic swelling ("cytotoxic" oedema) was seen three hours to three days after injury, maximal in perivascular foot processes, and compressing some of the underlying capillaries. The tight junctions were not disrupted. Neuronal damage was most marked three to 11 days after injury. The pathophysiological mechanisms leading to oedema formation and neuronal degeneration are discussed.