Autophagosome Biogenesis in Plants: An Actin Cytoskeleton Perspective
Autophagosome Biogenesis in Plants: An Actin Cytoskeleton Perspective
复制标题
植物中自噬体的生物发生：肌动蛋白细胞骨架的视角
DOI：
10.1016/j.tplants.2020.03.011
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发表时间：
2020
影响因子：
20.5
通讯作者：
Patrick J. Hussey
中科院分区：
文献类型：
--
作者：
Pengwei Wang;Erlin Gao;Patrick J. Hussey
在亚细胞水平，细胞骨架调节细胞结构、细胞器运动和细胞质流动。自噬是一种通过被称为自噬体的双膜隔室去除不需要的生物材料或受损细胞器的过程。自噬体的生物发生需要囊泡在供体和受体室之间的运输、膜扩张和融合，这很可能受到细胞骨架的调节。最近的研究表明，通过敲除关键的肌动蛋白调节蛋白，自噬体的生物合成被抑制。然而，当整个肌动蛋白网络被破坏时，ATG8阳性结构的形成不受影响。在这里，我们讨论这个矛盾，并提出肌动蛋白细胞骨架在植物自噬的功能。
At the subcellular level, the cytoskeleton regulates cell structure, organelle movement, and cytoplasmic streaming. Autophagy is a process to remove unwanted biomaterials or damaged organelles through double membrane compartments known as autophagosomes. Autophagosome biogenesis requires vesicle trafficking between donor and acceptor compartments, membrane expansion, and fusion, which is very likely to be regulated by the cytoskeleton. Recent studies have demonstrated that by knocking out key actin-regulating proteins, autophagosome biogenesis is inhibited. However, the formation of ATG8 positive structures are not affected when the entire actin network is disrupted. Here, we discuss this paradox and propose the function of the actin cytoskeleton in plant autophagy.