Pathophysiology and management of HIV-associated hematologic disorders.
Pathophysiology and management of HIV-associated hematologic disorders.
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DOI：
10.1182/blood.v74.5.1455.bloodjournal7451455
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发表时间：
1989-10
期刊：
影响因子：
20.3
通讯作者：
D. Scadden;L. Zon;J. Groopman
中科院分区：
文献类型：
--
作者：
D. Scadden;L. Zon;J. Groopman
被确定为获得性免疫缺陷综合征（艾滋病）的致病因子。感染这种病毒与广泛的临床结果有关，在造血系统中尤其明显。HIV感染后出现造血功能受损、免疫介导的细胞减少和凝血参数改变。这篇综述将讨论与HIV相关的血液学异常的临床表现、假定的病理生理和目前的治疗方法。
identified as the causal agent for the acquired immunodeficiency syndrome (AIDS). Infection with this virus has been associated with a broad range of clinical outcomes, particularly evident in the hematopoietic system. Impaired hematopoiesis, immune-mediated cytopenia, and altered coagulation parameters have been described following HIV infection. This review will discuss the clinical manifestations, postulated pathophysiology, and current therapeutic approaches to the hematologic abnormalities associated with HIV.