The association of DNA Repair with breast cancer risk in women. A comparative observational study.
The association of DNA Repair with breast cancer risk in women. A comparative observational study.
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DNA修复与女性乳腺癌风险的关联。比较观察性研究。
DOI：
10.1186/1471-2407-12-490
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发表时间：
2012-10-22
期刊：
影响因子：
3.8
通讯作者：
Bayona M
中科院分区：
文献类型：
--
作者：
Matta J;Echenique M;Negron E;Morales L;Vargas W;Gaetan FS;Lizardi ER;Torres A;Rosado JO;Bolaños G;Cruz JG;Laboy J;Barnes R;Medina SS;Romero A;Martinez R;Dutil J;Suarez E;Alvarez-Garriga C;Bayona M
以前的研究发现，DNA修复能力（DRC）水平低与癌症风险增加之间存在联系。我们的目的是在西班牙裔社区进行病例对照流行病学研究，评估DRC水平与乳腺癌（BC）的统计学关联。我们进行了一项比较观察研究，以评估DRC在整个波多黎各的824名妇女中检测BC的有效性。在6年的时间里，我们将285名新诊断为BC的女性与539名没有BC的女性进行了比较。通过宿主细胞再活化试验测量淋巴细胞中的DRC水平。我们使用受试者工作特征曲线分析评估敏感性、特异性和相关性。在同时调整所有混杂因素后，估计多重logistic回归调整的比值比（95%置信水平），以测量DRC和BC相关性的强度。与未患癌症的女性相比，患有BC的女性的DRC水平平均下降60%（p < 0.001）。DRC作为BC风险测量的相关性的有效性显示敏感性为83.2%，特异性为77.6%（p < 0.0001）。我们的研究结果支持DRC水平作为衡量BC风险的有用性。需要在其他人群中进行更多的研究，以进一步验证其有效性。
Previous studies have found a link between a low DNA repair capacity (DRC) level and increased cancer risk. Our aim was to assess the statistical association of DRC level and breast cancer (BC) using a case–control epidemiological study in a Hispanic community. We conducted a comparative observational study to assess the validity of DRC in detecting BC in 824 women throughout Puerto Rico. Over a 6-year period, we compared 285 women newly diagnosed with BC to 539 without BC. DRC levels were measured in lymphocytes by means of a host-cell reactivation assay. We assessed the sensitivity, specificity, and association using the receiver operating characteristic curve analysis. Multiple logistic regression-adjusted odds ratios were estimated with 95% confidence level to measure the strength of the association of DRC and BC after adjusting for all confounders simultaneously. Compared to women without cancer, women with BC showed an average decrease of 60% in their DRC levels (p < 0.001). Validity of the association of DRC as a measure of BC risk showed a sensitivity of 83.2% and specificity of 77.6% (p < 0.0001). Our results support the usefulness of DRC level as a measure of BC risk. Additional studies in other populations are needed to further verify its usefulness.
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影响因子：
4.9
作者：
METZ, CE
通讯作者：
METZ, CE
影响因子：
11.2
作者：
Hu, JJ;Hall, MC;Case, LD
通讯作者：
Case, LD
影响因子：
10.3
作者：
Kennedy, DO;Agrawal, M;Santella, RM
通讯作者：
Santella, RM
DOI：
10.1093/jnci/88.11.754
发表时间：
1996-06-05
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Helzlsouer, KJ;Harris, EL;Sanford, KK
通讯作者：
Sanford, KK
影响因子：
10.3
作者：
Landi, MT;Baccarelli, A;Grossman, L
通讯作者：
Grossman, L