A new secoiridoid glycoside and a new sesquiterpenoid glycoside from Valeriana jatamansi with neuroprotective activity
A new secoiridoid glycoside and a new sesquiterpenoid glycoside from Valeriana jatamansi with neuroprotective activity
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DOI：
10.1016/j.phytol.2016.07.020
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发表时间：
2016-09
影响因子：
1.7
通讯作者：
Tan Yuzhu;Y. Yong;Yan-hong Dong;Wang Rujing;Hong-xiang Li;Hai Zhang;Da-le Guo;Shi-Jin Zhang;X. Dong;Xiaofang Xie
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文献类型：
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作者：
Tan Yuzhu;Y. Yong;Yan-hong Dong;Wang Rujing;Hong-xiang Li;Hai Zhang;Da-le Guo;Shi-Jin Zhang;X. Dong;Xiaofang Xie
从缬草根中分离出一种新的环烯醚萜苷，异败酱草苷 (1) 和一种新的倍半萜苷，缬草素 F (2)，以及九种已知化合物。在光谱分析的基础上阐明了它们的结构。化合物1是一种罕见的单环环烯醚萜苷，由吡喃环裂解产生，在C-1和C-2之间开环。在 11 个分离株中，化合物 1 和 4 对 CoCl2 诱导的 PC12 细胞神经元细胞死亡表现出中等的神经保护作用。
A new secoiridoid glycoside, isopatrinioside (1) and a new sesquiterpenoid glycoside, valeriananoid F (2), together with nine known compounds, were isolated from the roots ofValeriana jatamansi. Their structures were elucidated on the basis of spectroscopic analysis. Compound1was an unusual monocyclic iridoid glycoside ring-opened between C-1 and C-2 produced by the cleavage of the pyran ring. Of the eleven isolates, compounds1and4exhibited moderate neuroprotective effects against CoCl2-induced neuronal cell death in PC12 cells.