PANCREATIC DUCT PRESSURE, DUCT PERMEABILITY AND ACUTE-PANCREATITIS
PANCREATIC DUCT PRESSURE, DUCT PERMEABILITY AND ACUTE-PANCREATITIS
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DOI：
10.1002/bjs.1800760832
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发表时间：
1989-08-01
影响因子：
9.6
通讯作者：
REBER, HA
中科院分区：
文献类型：
--
作者：
HARVEY, MH;WEDGWOOD, KR;REBER, HA
本文用猫急性胰腺炎模型研究了胰管压力、胰管大分子通透性与急性胰腺炎发生的关系。用15 mM甘氨脱氧胆酸灌注胰管，给予乙醇或促分泌素刺激胰腺分泌以对抗> 50%的胰管阻塞，导致所有动物的胰管峰值压力增加。29只实验动物中有22只对分子量为20000的右旋糖酐分子的通透性增加，与22只对照动物中的2只相比（P<0.01）。29只实验动物中有24只经胰管灌注激活的胰酶后发生急性胰腺炎，22只对照动物中有3只发生急性胰腺炎（P<0.01）。这些结果表明，胰腺导管高压，导致导管通透性增加的大分子，可能是一个常见的早期事件，胆结石和酒精性胰腺炎。
The relationship between pancreatic duct pressure, duct permeability to macromolecules and the development of acute pancreatitis was studied in a cat model. Perfusion of the pancreatic duct with 15 mM glycodeoxycholic acid, ethanol administration, or secretagogue-stimulated pancreatic secretion against > 50 per cent duct obstruction resulted in an increase in peak pancreatic duct pressure in all animals. Duct permeability to 20 000 molecular weight dextran molecules was increased in 22 of 29 experimental animals compared with two of 22 control animals (P<0·01). Perfusion of the pancreatic duct with activated pancreatic enzymes resulted in acute pancreatitis in 24 of 29 experimental animals compared with three of 22 control animals (P<0·01). These results suggest that pancreatic ductal hypertension, resulting in increased ductal permeability to large molecules, may be a common early event in gallstone and alcoholic pancreatitis.