Plasma cortisol transport and primate evolution.
Plasma cortisol transport and primate evolution.
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血浆皮质醇运输和灵长类动物进化。
DOI：
10.1210/endo-115-1-357
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发表时间：
1984
期刊：
影响因子：
4.8
通讯作者：
M. Lipsett
中科院分区：
文献类型：
--
作者：
M. Pugeat;G. Chrousos;B. C. Nisula;D. Loriaux;D. Brandon;M. Lipsett
灵长类动物已经分化成三个主要的进化群体：原猴、旧世界灵长类和新世界灵长类;最后一个群体的特征是高循环皮质醇浓度和对糖皮质激素作用的抵抗。我们已经研究了大范围的灵长类物种在这些群体中的皮质醇结合球蛋白（CBG）的系统发育关系的特点。在每个物种中的CBG被发现是糖基化的，从凝集素相互作用判断，并表现出类似于人CBG的电泳迁移率。虽然CBG对皮质醇的亲和力在物种间不同，但温度变化对CBG亲和力的影响是相似的。引人注目的是，新世界灵长类动物血浆中的CBG结合能力是旧世界灵长类动物和原猴亚目动物的1/10到1/100，而CBG与皮质醇的结合亲和力较低。CBG的能力和亲和力的降低导致新世界灵长类动物中未结合血浆皮质醇的分数明显高于旧世界灵长类动物或所研究的原猴属物种。CBG的这种进化模式可能是新大陆猴靶器官对糖皮质激素抵抗的一种补偿机制。
Primates have diverged into three major evolutionary groups: prosimians, Old World primates, and New World primates; the last group is distinguished by high circulating cortisol concentrations and resistance to the action of glucocorticoids. We have studied a large spectrum of primate species within these groups to characterize the phylogenetic relationships of cortisol-binding globulin (CBG) among them. The CBG in each species was found to be glycosylated, as judged from lectin interactions, and to exhibit an electrophoretic mobility similar to that of human CBG. Although the CBG affinity for cortisol differed among species, the effects of changes in temperature on the CBG affinity were similar. Strikingly, the CBG-binding capacity of plasma in the New World primates was 1/10th to 1/100th those in the Old World primates and prosimians, while the CBG-binding affinity for cortisol was lower. The reduced capacity and affinity of CBG result in a markedly higher fraction of unbound plasma cortisol in the New World primates than in the Old World primates or the prosimian species examined. This evolutionary pattern of CBG may be a compensatory mechanism for the target organ resistance to glucocorticoids that characterizes the New World monkeys.
类固醇激素的血清转运。
DOI：
10.1016/b978-0-12-571138-8.50016-0
发表时间：
1982
期刊：
Recent progress in hormone research
影响因子：
--
作者：
Siiteri,PK;Murai,JT;Hammond,GL;Nisker,JA;Raymoure,WJ;Kuhn,RW
通讯作者：
Kuhn,RW