Neural response to alcohol stimuli in adolescents with alcohol use disorder
Neural response to alcohol stimuli in adolescents with alcohol use disorder
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DOI：
10.1001/archpsyc.60.7.727
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发表时间：
2003-07-01
影响因子：
--
通讯作者：
Brown, SA
中科院分区：
文献类型：
--
作者：
Tapert, SF;Cheung, EH;Brown, SA
背景资料：对酒精依赖成年人的线索反应性研究表明，酒精相关刺激的非典型生理、认知和神经反应不同于轻度饮酒者的反应。提示反应性及其神经基质在青年中尚不清楚。我们假设，酒精使用障碍的青少年会表现出更大的大脑反应比非滥用青少年酒精的图像相对于中性饮料的图像在边缘和额叶brainregions.Methods：我们测试的假设在一个横截面功能磁共振成像研究。从当地高中招募了14至17岁的青少年。患有酒精使用障碍的青少年（n = 15）和人口统计学上相似的不常饮酒者（n = 15）符合严格的排除标准（无左撇子或神经、其他精神或其他物质使用障碍）。通过结构化和半结构化临床访谈确定诊断。受试者在血氧水平依赖性功能磁共振成像过程中被展示酒精和非酒精饮料广告的图片。自我报告的渴望之前和之后的线索exposation.Results：酒精使用障碍的青少年表现出显着更大的大脑激活酒精饮料图片比对照组青年，主要是在左前，边缘系统，视觉系统领域（P <0.05，集群阈值，515穆尔）。酒精图片的大脑反应的程度是最高的年轻人谁消耗更多的饮料，每个月，并报告更大的欲望drink.Conclusions：这些结果证实了以前的研究，通过展示之间的关联的冲动喝酒和血氧使用的大脑区域以前联系到奖励，欲望，积极的影响，和情节回忆。本研究将这种关系扩展到使用视觉酒精刺激的饮酒史相对较短的青少年，并提出了饮酒问题的青少年对酒精广告反应的神经基础。
Background: Cue reactivity studies in alcohol-dependent adults have shown atypical physiological, cognitive, and neural responses to alcohol-related stimuli that differ from the responses of light drinkers. Cue reactivity and its neural substrates are unclear in youth. We hypothesized that teens with alcohol use disorder would show greater brain response than nonabusing teens to alcohol images relative to neutral beverage images in limbic and frontal brain regions.Methods: We tested the hypotheses in a cross-sectional functional magnetic resonance imaging study. Adolescents aged 14 to 17 were recruited from local high schools. Teens with alcohol use disorders (n = 15) and demographically similar infrequent drinkers (n = 15) met strict exclusion criteria (no left-handedness or neurological, other psychiatric, or other substance use disorders). Diagnoses were determined by means of structured and semistructured clinical interviews. Subjects were shown pictures of alcoholic and nonalcoholic beverage advertisements during blood oxygen level-dependent functional magnetic resonance imaging. Self-reports of craving were obtained before and after cue exposure.Results: Teens with alcohol use disorders showed substantially greater brain activation to alcoholic beverage pictures than control youths, predominantly in the left anterior, limbic, and visual system areas (P < .05; cluster threshold, 515 muL). The degree of brain response to the alcohol pictures was highest in youths who consumed more drinks per month and reported greater desires to drink.Conclusions: These results confirm previous studies by demonstrating an association between the urge to drink alcohol and blood oxygen use in areas of the brain previously linked to reward, desire, positive affect, and episodic recall. This study extends this relationship to adolescents with relatively brief drinking histories using visual alcohol stimuli, and suggests a neural basis for response to alcohol advertisements in youths with drinking problems.