Activation of the prefrontal cortex during judgments of recency: a functional MRI study.
Activation of the prefrontal cortex during judgments of recency: a functional MRI study.
复制标题
判断新近度时前额皮质的激活：一项功能性 MRI 研究。
DOI：
10.1097/00001756-199611040-00079
复制
发表时间：
1996
期刊：
影响因子：
1.7
通讯作者：
D'Esposito,M
中科院分区：
文献类型：
--
作者：
Zorrilla,LT;Aguirre,GK;Zarahn,E;Cannon,TD;D'Esposito,M
动物和人类损伤研究一致表明，前额叶损伤会破坏需要记忆时间背景的任务的表现。在这项研究中，功能性磁共振成像（fMRI）被用来探索与健康人的相对近的判断相关的大脑区域。双侧背外侧前额叶皮层（布罗德曼区[BA] 9）在言语近因判断任务中比在非记忆控制任务中更活跃。在中线辅助运动区（BA 6）和左侧楔前叶（BA 7）也观察到与时间背景识别相关的激活。这项研究提供了进一步的证据，证明时间背景的记忆需要前额叶皮层，并且是第一个在健康人中证明这种联系的研究。目前的研究结果还表明，识别上下文和识别情节内容可能涉及类似的大脑系统。
ANIMAL and human lesion studies have consistently shown that damage to the prefrontal lobe disrupts performance on tasks requiring memory for temporal context. In this study, functional magnetic resonance imaging (fMRI) was used to explore the brain regions associated with judgments of relative recency in healthy humans. Bilateral dorsolateral prefrontal cortex (Brodmann's area [BA] 9) was more active during a verbal recency judgment task than during a non-mnemonic control task. Activation related to temporal context recognition was also observed in midline supplementary motor area (BA 6) and left precuneus (BA 7). This study provides further evidence that memory for temporal context requires the prefrontal cortex and is the first to demonstrate this association in healthy humans. The current findings also suggest the possibility that recognition of context and recognition of episodic content may involve similar brain systems.