Magnetic Hybrid Wax Nanocomposites as Externally Controlled Theranostic Vehicles: High MRI Enhancement and Synergistic Magnetically Assisted Thermo/Chemo Therapy
Magnetic Hybrid Wax Nanocomposites as Externally Controlled Theranostic Vehicles: High MRI Enhancement and Synergistic Magnetically Assisted Thermo/Chemo Therapy
复制标题
DOI：
10.1002/chem.201904709
复制
发表时间：
2020-02-21
影响因子：
4.3
通讯作者：
Banobre-Lopez, Manuel
中科院分区：
文献类型：
--
作者：
de Moura, Carolina L.;Gallo, Juan;Banobre-Lopez, Manuel
为了对抗癌症，需要更智能的药物和药物递送系统，既要提高现有治疗的效率，同时减少有害副作用，又要将诊断/监测与治疗（诊疗一体化）相结合，以追求个性化医疗的最终目标。这项工作介绍了一种新型有机 - 无机杂化纳米复合材料的设计、制备以及原理验证。该材料通过磁共振成像结合了非侵入性成像能力，并通过化学疗法和热疗法的结合具备了外部驱动的治疗特性。纳米复合材料的脂质基质由巴西棕榈蜡组成，它同时负载了磁铁矿纳米颗粒和抗癌药物Oncocalyxone A。所获得的制剂经过了全面表征，在磁共振成像中作为T - 2造影剂表现出卓越性能（r(2)>800 mm(-1)s(-1)），在磁热疗中作为发热源（比吸收率，SAR>200 W g(Fe)(-1)），并且是磁响应性药物递送载体。所设计的制剂作为诊疗试剂的潜力在体外得到了验证，结果表明，热量产生以及对癌症生长的药物控制递送产生了协同的热/化学治疗效果。因此，这种对药物递送特性的外部控制以及集成的成像能力为个性化癌症医疗和肿瘤进展的实时监测打开了大门。
To fight against cancer, smarter drugs and drug delivery systems are required both to boost the efficiency of current treatments while reducing deleterious side effects, and combine diagnosis/monitoring with therapy (theranosis) in the search for the final goal of personalized medicine. This work presents the design, preparation, and proof-of-principle validation of a novel hybrid organic-inorganic nanocomposite joining together non-invasive imaging capabilities through magnetic resonance imaging and externally actuated therapeutic properties through a combination of chemo- and thermotherapy. The lipidic matrix of the nanocomposite was composed of carnauba wax, which was simultaneously dual loaded with magnetite nanoparticles and the anticancer drug Oncocalyxone A. Obtained formulations were fully characterized and showed outstanding performances as T-2-contrast agents in magnetic resonance imaging (r(2)>800 mm(-1) s(-1)), heat generating sources in magnetic hyperthermia (specific absorption rate, SAR>200 W g(Fe)(-1)), and magnetically responsive drug delivery vehicles. The potential of the designed formulations as theranostic agents was validated in vitro and results indicated a synergistic thermo/chemotherapeutic effect derived from heat generation and controlled drug delivery to cancer growth. Thereby, this external control over the drug delivery profile and the integrated imaging capability open the door to personalized cancer medicine and real-time monitoring of tumor progression.