The unfolding story of the Escherichia coli Hsp70 DnaK: is DnaK a holdase or an unfoldase?
The unfolding story of the Escherichia coli Hsp70 DnaK: is DnaK a holdase or an unfoldase?
复制标题
大肠杆菌 Hsp70 DnaK 的故事展开：DnaK 是保持酶还是解折叠酶？
DOI：
10.1046/j.1365-2958.2002.03093.x
复制
发表时间：
2002
影响因子：
3.6
通讯作者：
Witt,StephanN
中科院分区：
文献类型：
--
作者：
Slepenkov,SergeyV;Witt,StephanN
We discuss recent experiments that have illuminated individual steps in the reaction cycle of theEscherichia coliHsp70 molecular chaperone DnaK. Using this new information, we comparetwo distinctly different global mechanisms of action – holding versus unfolding – and argue that the available evidencesuggests that DnaK is an unfoldase.
