The effect of chromium picolinate on serum cholesterol and apolipoprotein fractions in human subjects.
The effect of chromium picolinate on serum cholesterol and apolipoprotein fractions in human subjects.
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吡啶甲酸铬对人类受试者血清胆固醇和载脂蛋白组分的影响。
DOI：
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发表时间：
1990
期刊：
影响因子：
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通讯作者：
G. Evans
中科院分区：
文献类型：
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作者：
R. Press;J. Geller;G. Evans
铬被认为是维持正常脂质和碳水化合物代谢的辅助因子。缺乏铬的原因是饮食中生物有效铬含量低。吡啶甲酸是色氨酸的代谢产物，与过渡金属离子形成稳定的络合物，这导致金属离子铬的生物利用度提高。为了确定吡啶甲酸铬是否对人类有效，在一项双盲交叉研究中，28名志愿受试者每天给予三吡啶甲酸铬（3.8微摩尔[200微克]铬）或安慰剂42天。两次治疗之间停药14天。总胆固醇、低密度脂蛋白（LDL）胆固醇和载脂蛋白B（LDL组分的主要蛋白质）的水平在受试者摄入吡啶甲酸铬时显著降低。载脂蛋白A-I的浓度，高密度脂蛋白（HDL）组分的主要蛋白质，在吡啶甲酸铬治疗期间大幅增加。HDL-胆固醇水平略有升高，但不显着摄入吡啶甲酸铬。只有载脂蛋白B，测量的变量，在补充安慰剂的显着改变。这些观察结果表明，吡啶甲酸铬在降低人类血脂方面是有效的。
Chromium has been implicated as a cofactor in the maintenance of normal lipid and carbohydrate metabolism. A deficiency of chromium results from diets low in biologically available chromium. Picolinic acid, a metabolite of tryptophan, forms stable complexes with transitional metal ions, which results in an improved bioavailability of the metal ion chromium. To determine whether or not chromium picolinate is effective in humans, 28 volunteer subjects were given either chromium tripicolinate (3.8 micromol [200 micrograms] chromium) or a placebo daily for 42 days in a double-blind crossover study. A 14-day period off capsules was used between treatments. Levels of total cholesterol, low-density lipoprotein (LDL) cholesterol, and apolipoprotein B, the principal protein of the LDL fraction, decreased significantly while the subjects were ingesting chromium picolinate. The concentration of apolipoprotein A-I, the principal protein of the high-density lipoprotein (HDL) fraction, increased substantially during treatment with chromium picolinate. The HDL-cholesterol level was elevated slightly but not significantly during ingestion of chromium picolinate. Only apolipoprotein B, of the variables measured, was altered significantly during supplementation with the placebo. These observations show that chromium picolinate is efficacious in lowering blood lipids in humans.
脂质研究诊所冠状动脉一级预防试验结果。
DOI：
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发表时间：
1984
期刊：
JAMA
影响因子：
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作者：
通讯作者：
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脂质研究诊所冠状动脉一级预防试验结果。
DOI：
10.1001/jama.1984.03340270029025
发表时间：
1984
期刊：
JAMA
影响因子：
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作者：
通讯作者：
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