Bipolar spectrum disorders are associated with increased gray matter volume in the medial orbitofrontal cortex and nucleus accumbens.
Bipolar spectrum disorders are associated with increased gray matter volume in the medial orbitofrontal cortex and nucleus accumbens.
复制标题
双相谱系障碍与内侧眶额皮质和伏核灰质体积增加有关。
DOI：
10.1002/jcv2.12068
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Nusslock,Robin
中科院分区：
文献类型：
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作者：
Damme,KatherineSF;Alloy,LaurenB;Kelley,NicholasJ;Carroll,Ann;Young,ChristinaB;Chein,Jason;Ng,TommyH;Titone,MadisonK;Bart,CorinneP;Nusslock,Robin
目的提高对奖励的敏感性可预测双相情感障碍(BSD)的发病；然而，尚不清楚体积异常是否也反映了BSD的风险。当额叶和纹状体区域的关键神经发育以性别特有的方式发生时，BSD就会出现。本研究采用探索性分析方法，对BSD患者和BSD高危人群的额叶和纹状体脑区体积进行了研究。方法114名18-27岁、低BSD风险人群(中等奖赏敏感度；N=0.37)、高危BSD人群(高奖赏敏感度；N=0.47)或BSD高危人群(N=0.30)完成了脑部结构MRI扫描。结果BSD组较低个体(d=1.01)，额纹状体体积(mOFC，NAcc)增大。BSD组mOFC体积大于低危组(d=1.01)和高危组(d=0.74)。这种影响是由患有BSD的男性推动的，与低风险(d=11.01)和高危男性(d=60.74)相比，他们的mOFC更大。患有BSD的男性NAcc体积也高于低风险男性(d=0.49)，但不是高危男性。结论额纹状体体积增大(平均mOFC，NAcc)与BSD的存在有关，而亚体积(mOFC与NAcc)在风险方面显示出独特的模式。我们报告了初步证据表明，在BSD中，性别调节额纹状体体积，强调了更大的纵向风险研究的必要性，以检验特定性别的神经发育轨迹在新出现的BSD中的作用。
ObjectiveElevated sensitivity to rewards prospectively predicts Bipolar Spectrum Disorder (BSD) onset; however, it is unclear whether volumetric abnormalities also reflect BSD risk. BSDs emerge when critical neurodevelopment in frontal and striatal regions occurs in sex‐specific ways. The current paper examined the volume of frontal and striatal brain regions in both individuals with and at risk for a BSD with exploratory analyses examining sex‐specificity.MethodsOne hundred fourteen medication‐free individuals ages 18–27 at low‐risk for BSD (moderate‐reward sensitivity;N= 37), at high‐risk without a BSD (high‐reward sensitivity;N= 47), or with a BSD (N= 30) completed a structural MRI scan of the brain. We examined group differences in gray matter volume in a priori medial orbitofrontal cortex (mOFC) and nucleus accumbens (NAcc) regions‐of‐interest.ResultsThe BSD group had enlarged frontostriatal volumes (mOFC, NAcc) compared to low individuals (d= 1.01). The mOFC volume in BSD was larger than low‐risk (d= 1.01) and the high‐risk groups (d= 0.74). This effect was driven by males with a BSD, who showed an enlarged mOFC compared to low (d= 1.01) and high‐risk males (d= 0.74). Males with a BSD also showed a greater NAcc volume compared to males at low‐risk (d= 0.49), but not high‐risk males.ConclusionsAn enlarged frontostriatal volume (averaged mOFC, NAcc) is associated with the presence of a BSD, while subvolumes (mOFC vs. NAcc) showed unique patterning in relation to risk. We report preliminary evidence that sex moderates frontostriatal volume in BSD, highlighting the need for larger longitudinal risk studies examining the role of sex‐specific neurodevelopmental trajectories in emerging BSDs.