Bright light treatment of winter depression - A placebo-controlled trial
Bright light treatment of winter depression - A placebo-controlled trial
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DOI：
10.1001/archpsyc.55.10.883
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发表时间：
1998-10-01
影响因子：
--
通讯作者：
Meaden, PM
中科院分区：
文献类型：
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作者：
Eastman, CI;Young, MA;Meaden, PM
背景：亮光疗法是冬季季节性情感障碍（SAD）的推荐治疗方法。然而，最好的安慰剂对照的研究还没有能够证明，光治疗有一个好处超出其安慰剂effects.Methods：96例SAD患者完成了这项研究。患者被随机分配到3种治疗中的一种，持续4周，每天1.5小时：早晨光照（平均开始时间约为6 AM），晚上光照（平均开始时间约为9 PM）或早晨安慰剂（平均开始时间约为6 AM）。产生了明亮的光（大约6000勒克斯）。而安慰剂组是假的负离子发生器。采用汉密尔顿抑郁量表SAD版结构化访谈指南（SIGH-SAD）每周进行一次抑郁评分。结果：治疗4周后，3组患者的期望评分和平均抑郁评分均无差异。然而，严格的反应标准显示了统计学上的显著差异;治疗3周后，与安慰剂相比，晨光产生了更多的完全或几乎完全缓解。根据1项标准（24项SIGH-SAD评分
Background: Bright light therapy is the recommended treatment for winter seasonal affective disorder (SAD). However, the studies with the best placebo controls have not been able to demonstrate that light treatment has a benefit beyond its placebo effect.Methods: Ninety-six patients with SAD completed the study. Patients were randomly assigned to 1 of 3 treatments for 4 weeks, each 1.5 hours per day: morning light (average start time about 6 AM), evening light (average start about 9 PM), or morning placebo (average start about 6 AM). The bright light (approximate to 6000 lux) was produced. by light boxes, and the placebos were sham negative-ion generators. Depression ratings using the Structured Interview Guide for the Hamilton Depression Rating Scale, SAD version (SIGH-SAD) were performed weekly.Results: There were no differences among the 3 groups in expectation ratings or mean depression scores after 4 weeks of treatment. However, strict response criteria revealed statistically significant differences; after 3 weeks of treatment morning light produced more of the complete or almost complete remissions than placebo. By 1 criterion (24-item SIGH-SAD score