Understanding the Effectiveness of Natural Compound Mixtures in Cancer through Their Molecular Mode of Action.
Understanding the Effectiveness of Natural Compound Mixtures in Cancer through Their Molecular Mode of Action.
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DOI：
10.3390/ijms18030656
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发表时间：
2017-03-17
影响因子：
5.6
通讯作者：
Adelson DL
中科院分区：
文献类型：
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作者：
Aung TN;Qu Z;Kortschak RD;Adelson DL
由于不良反应、耐药性或单一抗癌剂的靶特异性不足，许多癌症管理方法通常无效。相比之下，以其各自的有效剂量应用两种或更多种抗癌剂的组合方法可以实现增强对癌细胞的细胞毒性的协同效应。在癌症中，异常的细胞凋亡途径允许应该被杀死的细胞在遗传异常的情况下存活，导致癌症进展。在癌症治疗过程中通过癌症进展产生的凋亡机制突变可因此导致化学抗性。天然化合物混合物被认为具有多个特异性靶点，具有最小的可接受的副作用，由于其细胞毒性和化学增敏活性，现在引起许多研究人员的兴趣。药物混合物中的协同相互作用增强了对癌细胞中潜在分子靶点的搜索。尽管如此，来自天然产品的有偏见/有缺陷的科学证据可能会在药物筛选期间显示假阳性治疗益处。在这篇综述中，我们在讨论这些化合物的证据及其在癌症中的协同治疗益处时考虑了这些因素。虽然这些混合物的临床疗效证据有限，但体外数据表明，这些制剂值得进一步研究，包括体外和体内研究。
Many approaches to cancer management are often ineffective due to adverse reactions, drug resistance, or inadequate target specificity of single anti-cancer agents. In contrast, a combinatorial approach with the application of two or more anti-cancer agents at their respective effective dosages can achieve a synergistic effect that boosts cytotoxicity to cancer cells. In cancer, aberrant apoptotic pathways allow cells that should be killed to survive with genetic abnormalities, leading to cancer progression. Mutations in apoptotic mechanism arising during the treatment of cancer through cancer progression can consequently lead to chemoresistance. Natural compound mixtures that are believed to have multiple specific targets with minimal acceptable side-effects are now of interest to many researchers due to their cytotoxic and chemosensitizing activities. Synergistic interactions within a drug mixture enhance the search for potential molecular targets in cancer cells. Nonetheless, biased/flawed scientific evidence from natural products can suggest false positive therapeutic benefits during drug screening. In this review, we have taken these factors into consideration when discussing the evidence for these compounds and their synergistic therapeutic benefits in cancer. While there is limited evidence for clinical efficacy for these mixtures, in vitro data suggest that these preparations merit further investigation, both in vitro and in vivo.