The Incidence and Prevalence of Human Papilloma Virus-associated Cancers in IBD
The Incidence and Prevalence of Human Papilloma Virus-associated Cancers in IBD
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DOI：
10.1093/ibd/izaa035
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发表时间：
2021-01-01
影响因子：
4.9
通讯作者：
Faiz, Omar D.
中科院分区：
文献类型：
--
作者：
Segal, Jonathan P.;Askari, Alan;Faiz, Omar D.
目的：人乳头瘤病毒（HPV）与肛门、宫颈、阴道等部位均有相关性。和阴茎癌这项基于人群的研究的主要目的是确定HPV相关癌症是否在炎症性肠病（IBD）患者中更常见。方法：1997年至2012年的医院事件统计（HES）数据库，与年龄标准化率（ASR）相关，使用人口数据计算，采用考克斯回归分析IBD患者的生存率是否低于非IBD患者。其中，837例患者先前诊断为IBD（1.4%）。炎症性肠病患者的肛门癌ASR显著高于非IBD人群：IBD组为每10万人5.5例，而非IBD组为1.8例。IBD组也在较年轻的年龄被诊断为肛门癌（60岁与非IBD组的66岁相比，P <0.001）。IBD伴肛门癌患者的生存率也低于非IBD组（风险比，1.32; 95%可信区间，1.15 - 1.52; P <0.001）。平均而言，IBD伴肛门癌组的生存期（46个月）明显短于非IBD组（61个月，P <0.001）。IBD组宫颈癌的年龄标化率（5.2/100，000）显著高于非IBD组（4.6/100，000）（P = 0.042）。IBD组中肛门癌的生存率也更差。
Aim: The human papilloma virus has been associated with anal, cervical, vaginal. and penile cancers. The primary aim of this population-based study is to determine whether HPV-associated cancers are more commonplace in patients with inflammatory bowel disease (IBD).Method: The Hospital Episode Statistics (HES) database from 1997 to 2012, linked with officer for age standardized rates (ASR), were calculated using population data, and Cox regression analysis was used to determine whether IBD patients have poorer survival compared with non-IBD patients.Results: A total of 61,648 patients were included in this study; of these, 837 patients had a preexisting diagnosis of IBD (1.4%). Inflammatory bowel disease patients had a significantly higher ASR of anal cancers than the non-IBD population: 5.5 per 100,000 in the IBD group compared with 1.8 in the non-IBD group. The IBD group was also diagnosed with anal cancers at a younger age (60 years compared with 66 years in the non-IBD group, P < 0.001). The survival of IBD patients with anal cancer was also poorer than the non-IBD group (hazard ratio, 1.32; 95% confidence interval, 1.15-1.52; P < 0.001). On average, survival was significantly shorter in the IBD group with anal cancer (46 months) compared with the non-IBD group (61 months, P < 0.001). Age standardized rates for cervical cancer was significantly higher in the IBD group (5.2 of 100,000) compared with the non-IBD group (4.6 of 100,000 P = 0.042).Conclusion: Patients with IBD have a higher rate of anal cancer compared with the general population. Survival is also worse for anal cancers in the IBD group.