Comparison of Rates of Progression of Coronary Atherosclerosis in Patients With Diabetes Mellitus Versus Those With the Metabolic Syndrome
Comparison of Rates of Progression of Coronary Atherosclerosis in Patients With Diabetes Mellitus Versus Those With the Metabolic Syndrome
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DOI：
10.1016/j.amjcard.2010.01.359
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发表时间：
2010-06-15
影响因子：
2.8
通讯作者：
Nicholls, Stephen J.
中科院分区：
文献类型：
--
作者：
Bayturan, Ozgur;Tuzcu, E. Murat;Nicholls, Stephen J.
糖尿病（DM）和代谢综合征（MS）与不良心血管结局相关。然而，这些病症的冠状动脉粥样硬化的程度和进展尚未直接比较。 Three thousand four hundred fifty-nine patients with coronary artery disease underwent serial evaluation of atheroma burden by intravascular ultrasound.对患有 DM、MS 或两者均未诊断的患者的斑块负荷、进展和动脉重塑进行比较。在这三组中，多发性硬化症患者的个体心血管危险因素数量最多。 Patients with DM demonstrated more extensive atherosclerosis burden with a greater percent atheroma volume compared to patients with MS or those with neither diagnosis (40.3 +/- 9.0%, 37.6 +/- 8.9%, and 38.1 +/- 9.1%, p
Diabetes mellitus (DM) and metabolic syndrome (MS) are associated with adverse cardiovascular outcomes. However, the extent and progression of coronary atherosclerosis for these conditions have not been directly compared. Three thousand four hundred fifty-nine patients with coronary artery disease underwent serial evaluation of atheroma burden by intravascular ultrasound. Patients with DM, MS, or neither diagnosis were compared with regard to plaque burden, progression, and arterial remodeling. Among the 3 groups, patients with MS had the largest number of individual cardiovascular risk factors. Patients with DM demonstrated more extensive atherosclerosis burden with a greater percent atheroma volume compared to patients with MS or those with neither diagnosis (40.3 +/- 9.0%, 37.6 +/- 8.9%, and 38.1 +/- 9.1%, p