Periodic Nanomechanical Stimulation in a Biokinetics Model Identifying Anabolic and Catabolic Pathways Associated With Cartilage Matrix Homeostasis.
Periodic Nanomechanical Stimulation in a Biokinetics Model Identifying Anabolic and Catabolic Pathways Associated With Cartilage Matrix Homeostasis.
复制标题
生物动力学模型中的周期性纳米机械刺激识别与软骨基质稳态相关的合成代谢和分解代谢途径。
DOI：
10.1115/1.4002461
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Kohles,SeanS
中科院分区：
文献类型：
--
作者：
Saha,AsitK;Kohles,SeanS
增强现有的纳米技术来描述生物动力学调节过程中的物理化学相互作用，将有力地支持细胞和分子工程的努力。在最近开发的用于扩展静态加载的单细胞生物力学分析的适用性的数学模型中，提出了生物动力学调节阈值（Saha和Kohles，2010，“A Distinct Catabolic to Anabolic Threshold Due to Single-Cell Static Nanomechanical Stimulation in a Carbohydrates Biokenetic Model，”J. Nanotechnol.医学工程，1（3），第031005页）。结果描述了多尺度机械生物学的分解代谢合成代谢途径。在本研究中，我们扩展了数学模型，以继续探索受控微环境中的纳米级生物分子响应。在这里，我们介绍了一个动态的机械刺激调节软骨分子的合成。模型迭代表明，一个biomethematical机制平衡分解代谢和合成代谢状态之间的和谐识别。定义相对负荷限值以区分“健康”和“有害”生物分子积聚。所提出的数学框架提供了一个具体的算法，从中探索生物动力学调节。
Enhancing the available nanotechnology to describe physicochemical interactions during biokinetic regulation will strongly support cellular and molecular engineering efforts. In a recent mathematical model developed to extend the applicability of a statically loaded, single-cell biomechanical analysis, a biokinetic regulatory threshold was presented (Saha and Kohles, 2010, “A Distinct Catabolic to Anabolic Threshold Due to Single-Cell Static Nanomechanical Stimulation in a Cartilage Biokinetics Model,” J. Nanotechnol. Eng. Med., 1(3), p. 031005). Results described multiscale mechanobiology in terms of catabolic to anabolic pathways. In the present study, we expand the mathematical model to continue exploring the nanoscale biomolecular response within a controlled microenvironment. Here, we introduce a dynamic mechanical stimulus for regulating cartilage molecule synthesis. Model iterations indicate the identification of a biomathematical mechanism balancing the harmony between catabolic and anabolic states. Relative load limits were defined to distinguish between “healthy” and “injurious” biomolecule accumulations. The presented mathematical framework provides a specific algorithm from which to explore biokinetic regulation.