Controlled DNA compaction within chromatin: The tail-bridging effect
Controlled DNA compaction within chromatin: The tail-bridging effect
复制标题
染色质内受控 DNA 压缩：尾桥效应
DOI：
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
H. Schiessel
中科院分区：
文献类型：
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作者：
Frank Muehlbacher;Christian Holm;H. Schiessel
我们通过引入核小体的简单模型来研究核小体之间吸引力的机制，核小体是染色质复合物内 DNA 的基本包装单位：八尾胶体，一个带负电的球体，具有八个带相反电荷的柔性嫁接链，代表末端组蛋白尾。我们证明了我们的复合物是通过链桥的形成而被吸引的，并且这种吸引力可以通过改变尾部带电单体的比例来调节。这表明染色质压缩的物理机制，其中 DNA 浓缩程度可以通过生化手段控制，即组蛋白尾部赖氨酸的乙酰化和脱乙酰化。
We study a mechanism underlying the attraction between nucleosomes, the fundamental packaging units of DNA inside the chromatin complex, by introducing a simple model of the nucleosome: the eight-tail colloid, a negatively charged sphere with eight oppositely charged, flexible, grafted chains that represent the terminal histone tails. We demonstrate that our complexes are attracted via the formation of chain bridges and that this attraction can be tuned by changing the fraction of charged monomers on the tails. This suggests a physical mechanism of chromatin compaction where the degree of DNA condensation can be controlled via biochemical means, namely the acetylation and deacetylation of lysines in the histone tails.
DOI：
10.1073/pnas.0408867102
发表时间：
2005-06
影响因子：
11.1
作者：
Jian Sun;Qing Zhang;T. Schlick
通讯作者：
Jian Sun;Qing Zhang;T. Schlick