New developments in topical estrogen therapy
New developments in topical estrogen therapy
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DOI：
10.1016/s0015-0282(97)81846-8
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发表时间：
1997-01-01
影响因子：
6.7
通讯作者：
Jewelewicz, R
中科院分区：
文献类型：
--
作者：
Jewelewicz, R
目的：目的：回顾经皮E（2）治疗绝经后妇女的新进展。设计：通过文献检索（Medline）1966年至1995年的医学文献，以确定评价经皮E（2）的新研究。患者：月经期和绝经后妇女。结果：与口服雌激素一样，经皮E（2）缓解绝经期症状，逆转泌尿生殖道萎缩，并保护骨经济。最初的研究已经证明了透皮E（2）对心血管功能的有益作用。生活质量，患者满意度和依从性也改善了透皮E（2）。经皮给药的进展继续出现，包括低剂量系统和贴剂，维持血清E（2）水平为一个完整的7天periods.Conclusions（S）：经皮给药的新发展有可能增加绝经后妇女谁接受和长期雌激素替代疗法的依从性。
Objective: To review new developments in transdermal E(2) therapy in postmenopausal women.Design: A bibliographic search (Medline) of the medical literature from 1966 through 1995 was used to identify new studies evaluating transdermal E(2).Patient(s): Menopausal and postmenopausal women.Result(s): Like oral estrogen, transdermal E(2) relieves menopausal symptoms, reverses urogenital atrophy, and conserves bone economy. Initial studies have demonstrated beneficial effects of transdermal E(2) on cardiovascular function. Quality of life, patient satisfaction, and compliance also improve with transdermal E(2). Advances in transdermal delivery continue to emerge, including low-dose systems and patches that maintain serum E(2) levels for a full 7-day period.Conclusion(s): New developments in transdermal administration have the potential to increase the number of postmenopausal women who accept and are compliant with long-term estrogen replacement therapy.