Role of stromal-epithelial interactions in hormonal responses
Role of stromal-epithelial interactions in hormonal responses
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DOI：
10.1679/aohc.67.417
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发表时间：
2004-12-01
影响因子：
--
通讯作者：
Kurita, T
中科院分区：
文献类型：
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作者：
Cunha, GR;Cooke, PS;Kurita, T
类固醇性激素（17 β-雌二醇、睾酮、双氢睾酮和孕酮）和芳烃（如二恶英）调节男性和女性泌尿生殖道和乳腺中各自靶器官的上皮细胞增殖和分泌蛋白的产生和分化。最近的证据表明，基质-上皮相互作用对于介导这些分子对上皮细胞的影响至关重要。我们的研究结果表明，雌二醇，睾酮，孕酮和二恶英调节上皮细胞增殖（刺激或抑制）通过旁分泌机制，需要在基质中的适当受体。上皮中的雄激素受体（AR）、雌激素受体α（ER α）、孕酮受体（PR）或芳烃受体（AhR）对于上皮增殖的调节既不是必需的也不是充分的。此外，在前列腺发育期间，需要通过基质AR的信号传导来诱导前列腺上皮身份、导管形态发生和腺分化。上皮功能分化在前列腺、子宫和阴道中通过AR（前列腺）和ER α（子宫和阴道）调节。在这些器官中，上皮和基质类固醇受体都是上皮分化某些方面的类固醇调节所必需的，例如子宫中上皮分泌蛋白的产生以及阴道和前列腺中上皮角化（鳞状化生）。这些基质-上皮相互作用的机制基础知之甚少，但生长因子似乎是这些细胞-细胞相互作用的介质。
Steroid sex hormones (17beta-estradiol, testosterone, dihydrotestosterone, and progesterone) and aryl hydrocarbons such as the dioxins regulate epithelial proliferation and secretory protein production and differentiation in their respective target organs in male and female urogenital tracts and mammary glands. Recent evidence has demonstrated that stromal-epithelial interactions are critical for mediating the effects of these molecules on epithelial cells. Our results have indicated that estradiol, testosterone, progesterone, and dioxin regulate epithelial proliferation (stimulation or inhibition) via paracrine mechanisms requiring the appropriate receptor in the stroma. The androgen receptor (AR), estrogen receptor alpha (ERalpha), progesterone receptor (PR), or aryl hydrocarbon receptor (AhR) in the epithelium are neither necessary nor sufficient for the regulation of epithelial proliferation. Moreover, during prostatic development, signaling through the stromal AR is required to induce prostatic epithelial identity, ductal morphogenesis and glandular differentiation. Epithelial functional differentiation is regulated in the prostate, uterus, and vagina via AR (prostate) and ERalpha(uterus and vagina). In these organs both epithelial and stromal steroid receptors are required for steroidal regulation of certain aspects of epithelial differentiation such as epithelial secretory protein production in the uterus and epithelial cornification in the vagina and prostate (squamous metaplasia). The mechanistic basis of these stromal-epithelial interactions is poorly understood, but growth factors appear to be mediators of these cell-cell interactions.