Localized malignant mesothelioma
Localized malignant mesothelioma
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DOI：
10.1097/01.pas.0000165529.78945.dc
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发表时间：
2005-07-01
影响因子：
5.6
通讯作者：
Wick, MR
中科院分区：
文献类型：
--
作者：
Allen, TC;Cagle, PT;Wick, MR
局限性恶性间皮瘤是一种罕见的浆膜上界限清楚的肿瘤，显微镜下表现为弥漫性恶性间皮瘤，但没有任何扩散的证据。人们对他们的行为知之甚少。我们报告了23例新病例。就诊时的平均年龄为63岁，性别比约为2：1（男/女）。21例肿瘤位于胸膜，2例位于腹膜。16个肿瘤复制了弥漫性上皮间皮瘤的显微镜模式，6个混合上皮和肉瘤模式，1个是纯粹的肉瘤。手术切除肿瘤后，21例随访资料的患者中有10例在诊断后18个月至11年内无疾病证据存活。死亡的患者发生局部复发和转移，但没有弥漫性胸膜扩散。局限性恶性间皮瘤应与弥漫性恶性间皮瘤分开，因为它们的局限性表现，完全不同的生物学行为，以及更好的预后。
Localized malignant mesotheliomas are uncommon sharply circumscribed tumors of the serosal membranes with the microscopic appearance of diffuse malignant mesothelioma but without any evidence of diffuse spread. Little is known about their behavior. We report 23 new cases. The mean age at presentation was 63 years, and the sex ratio was approximately 2:1 (male/female). Twenty-one tumors were pleural and 2 were peritoneal. Sixteen tumors reproduced microscopic patterns of diffuse epithelial mesotheliomas, 6 had mixed epithelial and sarcomatous patterns, and 1 was purely sarcomatous. After surgical excision of the tumor, 10 of 21 patients with follow-up data were alive without evidence of disease from 18 months to 11 years after diagnosis. Patients who died had developed local recurrences and metastases, but none had diffuse pleural spread. Localized malignant mesotheliomas should be separated from diffuse malignant mesotheliomas because of their localized presentation, quite different biologic behavior, and far better prognosis.