Development of Poly(Lactic Acid)/Chitosan Co-Matrix Microspheres: Controlled Release of Taxol-Heparin for Preventing Restenosis
Development of Poly(Lactic Acid)/Chitosan Co-Matrix Microspheres: Controlled Release of Taxol-Heparin for Preventing Restenosis
复制标题
聚乳酸/壳聚糖复合基质微球的开发：控制释放紫杉醇-肝素以预防再狭窄
作者：
T. Chandy;Gundu H. R. Rao;Robert F. Wilson;G. S. Das
Smooth muscle cell proliferation plays a major role in the genesis of restenosis after angioplasty or vascular injury. Controlled release of appropriate drugs alone and in combinations is one approach for treating coronary obstructions, balloon angioplasty, restenosis associated with thrombosis, and calcification. We demonstrated the possibility of encapsulating taxol-loaded polylactic acid (PLA) microspheres within heparin-chitosan spheres to develop a prolonged release co-matrix form. The in vitro release profile of taxol and heparin from this co-matrix system was monitored in phosphate buffered saline pH 7.4, using an ultraviolet spectrophotometer. The amount of taxol/heparin release was initially much higher, followed by a constant slow release profile for a prolonged period. The initial burst release of taxol (15.8%) and heparin (32.7%) from the co-matrix was modified with polyethylene glycol coatings (13.5% and 25.4%, respectively, for 24 hr). From scanning electron microscopy studies, it appears that these drugs diffuse out slowly to the dissolution medium through the micropores of the co-matrix. However, the surface micropores were modified with polyethylene glycol (PEG) coatings for a constant slow release profile. This PEG-coated PLA/chitosan co-matrix may target drug combinations having synergestic effects for prolonged periods to treat restenosis.
影响因子：
14
作者：
Edelman, ER;Nathan, A;Karnovsky, MJ
通讯作者：
Karnovsky, MJ
兔颈动脉模型中开槽管镍钛合金和不锈钢支架引起的亚急性血栓形成和血管损伤。
影响因子：
37.8
作者：
Sheth,S;Litvack,F;Dev,V;Fishbein,MC;Forrester,JS;Eigler,N
通讯作者：
Eigler,N