Response preparation and response inhibition after lesions of the medial frontal lobe.
Response preparation and response inhibition after lesions of the medial frontal lobe.
复制标题
内侧额叶损伤后的反应准备和反应抑制。
作者：
M. Verfaellie;K. Heilman
两名患有慢性单侧内侧额叶病变（包括辅助运动区）的患者接受了反应准备和反应抑制的任务。与正常对照一样，左侧病变的患者确实受益于有关后续反应的准备信息，但右侧病变的患者却没有。在一项需要抑制不适当反应的任务中，左侧病变的患者再次表现正常。相反，右侧病变的患者在抑制病变对侧肢体方面存在严重问题。我们假设内侧额叶可能通过调节运动系统的兴奋性水平参与反应准备和反应抑制。我们的研究结果还表明，右半球可能在调节这些过程中发挥主导作用。
Two patients with chronic unilateral medial frontal lobe lesions, including the supplementary motor area, were given tasks of response preparation and response inhibition. Whereas the patient with a left-sided lesion, like normal controls, did benefit from preparatory information regarding a subsequent response, the patient with a right-sided lesion did not. On a task requiring the inhibition of an inappropriate response, the patient with a left-sided lesion again performed normally. Conversely, the patient with a right-sided lesion had significant problems inhibiting the extremity contralateral to the lesion. We postulate that the medial frontal lobe may participate in response preparation and response inhibition by modulating the levels of excitability of the motor systems. Our findings also suggest that the right hemisphere may have a dominant role in mediating these processes.
DOI：
10.1037//0096-3445.109.4.475
发表时间：
1980
期刊：
Journal of experimental psychology. General
影响因子：
--
作者：
Goodman,D;Kelso,JA
通讯作者：
Kelso,JA