25 Years’ Experience With the Biken Oka Strain Varicella Vaccine
25 Years’ Experience With the Biken Oka Strain Varicella Vaccine
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Biken Oka 水痘疫苗 25 年经验
DOI：
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
M. Takahashi
中科院分区：
文献类型：
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作者：
M. Takahashi
虽然通常认为水痘在儿童时期是一种良性疾病，但水痘不仅在免疫缺陷儿童等高危人群中是一种潜在的严重感染，在其他健康的成人和儿童中也是一种潜在的严重感染。并发症包括细菌重复感染、肺炎和脑炎，感染可能是致命的。水痘除了给临床疾病带来巨大负担外，还给社会带来了巨大的经济负担。在水痘感染缺乏令人满意的治疗方法的情况下，疫苗接种在预防该病及其后遗症方面具有重要作用。最初的Oka株水痘减毒活疫苗是1974年在日本Biken研究所开发的。Biken水痘疫苗自25年前研制以来，已经进行了大量的临床试验。该疫苗获得的丰富临床经验有助于证实其在健康和高危人群中的耐受性、免疫原性和有效性。疫苗接种已被证明可以预防临床感染，并对水痘的严重并发症提供有效保护。这篇历史综述总结了Biken水痘疫苗的长期临床经验，并证实该疫苗具有良好的耐受性，并提供对水痘感染的长期免疫力。
Although commonly considered a benign disease in childhood, varicella is a potentially serious infection not only in high risk groups such as children with immune deficiencies, but also in otherwise healthy adults and children. Complications include bacterial superinfections, pneumonia and encephalitis, and the infection can be fatal. In addition to the substantial burden of clinical disease, varicella presents a large economic burden to society. In the absence of a satisfactory treatment for varicella infection, vaccination has an important role in preventing the disease and its sequelae.The original Oka strain live attenuated varicella vaccine was developed in 1974 at the Biken Institute in Japan. Since its development more than 25 years ago, the Biken varicella vaccine has been studied in a large number of clinical trials. The wealth of clinical experience obtained with this vaccine serves to confirm its tolerability, immunogenicity and efficacy in both healthy and high risk individuals. Vaccination has been shown to prevent clinical infection and provide effective protection against the severe complications of varicella. This historical review summarises the long clinical experience with the Biken varicella vaccine and confirms that the vaccine is very well tolerated and provides long term immunity from varicella infection.
基于人群的水痘并发症研究。
影响因子：
8
作者：
Guess,HA;Broughton,DD;Melton3rd,LJ;Kurland,LT
通讯作者：
Kurland,LT