Muscle function in patients with primary hyperparathyroidism
Muscle function in patients with primary hyperparathyroidism
复制标题
原发性甲状旁腺功能亢进症患者的肌肉功能
作者：
C. Joborn;J. Rastad;E. Stålberg;G. Åkerström;S. Ljunghall
通过测量18名原发性甲状旁腺功能亢进（HPT）患者和20名健康对照者的电刺激和计算机分析肌肉抽搐，研究了胫前肌的肌肉收缩。HPT患者单次刺激时的肌颤张力（TT）低于对照组[分别为76 ± 24N（SD）和99 ± 33N，P < 0.05]。在高频刺激下，肌力的差异增加，在20 Hz刺激下，HPT患者的肌力是对照组的73%（P < 0.01）。HPT患者与对照组之间在单次肌肉抽动时的收缩时间和半松弛时间以及20秒和90秒最大自主收缩后的抽动增强方面均无差异。结果表明，原发性HPT患者的肌肉功能受损可能是其虚弱和全身疲劳症状的重要原因。
The muscle contraction of the anterior tibial muscle was investigated by measurements of electrically stimulated and computer‐analyzed muscle twitches in 18 unselected patients with primary hyperparathyroidism (HPT) and in 20 healthy control persons. The HPT patients had a lower muscle twitch tension (TT) at single stimulation, compared with the control group [76 ± 24 N (SD) and 99 ± 33 N respectively, P < 0.05]. At high‐frequency stimulation the difference in muscle force increased, and at 20 Hz stimulation the force in the HPT patients was 73% of that in the controls (P < 0.01). There were no differences between the HPT patients and the control persons in neither contraction time nor half relaxation time at single muscle twitch nor in twitch potentiation after 20 and 90 seconds maximal voluntary contraction. The results indicate that patients with primary HPT have an impaired muscle function of probable importance for their symptoms of weakness and generalized fatigue.