Bipolar disorder and dementia: where is the link?
Bipolar disorder and dementia: where is the link?
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DOI：
10.1111/j.1479-8301.2010.00348.x
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发表时间：
2011-03-01
期刊：
影响因子：
2
通讯作者：
Haffen, Emmanuel
中科院分区：
文献类型：
--
作者：
Masouy, Anais;Chopard, Gilles;Haffen, Emmanuel
双相情感障碍过程中出现的认知障碍已经被发现，最近的研究已经定义了这种病理的神经心理学特征，包括注意力、执行功能、记忆和语言障碍。然而，关于某些患者在双相情感障碍过程中出现痴呆症状的问题仍然存在：这是一种偶然的联系，还是双相情感障碍和痴呆之间存在联系？如果考虑后一种假设，那么痴呆的本质是什么，它可能被认为是双相情感障碍特有的痴呆？目前的临床，神经心理学和脑成像数据是不确定的，但与额颞叶痴呆的相似之处可能会突出。功能成像研究可能会提供答案以及更具体的神经心理学测试。双相情感障碍中认知损害的原因也提出了关于神经发育或神经退行性过程的问题，因为几个因素似乎影响认知，这两个过程可能同时发生。需要进行长期研究以确定双相情感障碍患者的认知功能恶化是稳定的还是进行性的。双相情感障碍患者也可能有不同的神经生物学亚组。
Cognitive disorders appearing in the course of bipolar disease have been identified, and recent studies have defined the neuropsychological characteristics of this pathology, which includes attention, executive function, memory and language disorders. However, questions remain concerning the appearance of dementia symptoms over the course of bipolar disorder in certain patients: is it a chance association or is there a connection between bipolar disorders and dementia? If the latter hypothesis is considered, what is the nature of the dementia, which might be considered as a dementia specific to bipolar disorder? Current clinical, neuropsychological and cerebral imaging data are inconclusive, but similarities with frontotemporal dementia might be highlighted. Functional imaging studies might provide answers as well as more specific tests in neuropsychology. The cause of cognitive damage in bipolar disease also raises questions concerning a neurodevelopmental or neurodegenerative process, because several factors seem to influence cognition and these two processes might occur simultaneously. Long-term studies are necessary to determine whether cognitive deterioration in bipolar disease is stable or progressive. There might also be different neurobiological subgroups of patients with bipolar disease.