Potential biomarkers for differentiation of benign prostatic hyperplasia and prostate cancer
Potential biomarkers for differentiation of benign prostatic hyperplasia and prostate cancer
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DOI：
10.1080/09674845.2010.11730306
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发表时间：
2010-01
影响因子：
1.9
通讯作者：
N. Melegy;H. A. Aboulella;A. Abul-Fadl;N. Mohamed
中科院分区：
文献类型：
--
作者：
N. Melegy;H. A. Aboulella;A. Abul-Fadl;N. Mohamed
Abstract This study aims to evaluate the role of free/total prostate-specific antigen (PSA) ratio, serum total sialic acid level and cathepsin D activity in the differentiation of prostate cancer and benign prostatic hyperplasia (BPH). The study looked at 100 patients with BPH, 75 patients with organ-confined or locally advanced prostate cancer, and a control group of 50 healthy volunteers. Prostate cancer patients showed significantly higher total sialic acid level and cathepsin D activity and lower free/total PSA ratio than those in the BPH group. The results suggest that combined measurement of serum total sialic acid and/or cathepsin D activity with free/total PSA ratio could serve as a useful adjunct to conventional diagnostics for the differentiation of prostate cancer and BPH.
