Synergy between efflux pump CmeABC and modifications in ribosomal proteins L4 and L22 in conferring macrolide resistance in Campylobacter jejuni and Campylobacter coli
Synergy between efflux pump CmeABC and modifications in ribosomal proteins L4 and L22 in conferring macrolide resistance in Campylobacter jejuni and Campylobacter coli
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DOI：
10.1128/aac.00616-06
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发表时间：
2006-11-01
影响因子：
4.9
通讯作者：
Payot, Sophie
中科院分区：
文献类型：
--
作者：
Cagliero, Cedric;Mouline, Christian;Payot, Sophie
用红霉素和泰乐素体外培养空肠弯曲杆菌和大肠弯曲杆菌大环内酯耐药突变体。这些突变体表现出核糖体蛋白L4 （G74D）和L22的修饰（插入在86位或98位）。观察到CmeABC外排泵和这些修饰在赋予大环内酯耐药方面的协同作用。
Macrolide-resistant mutants of Campylobacter jejuni and Campylobacter coli were selected in vitro using erythromycin and tylosin. These mutants exhibited modifications in the ribosomal proteins L4 (G74D) and L22 (insertions at position 86 or 98). A synergy between the CmeABC efflux pump and these modifications in conferring macrolide resistance was observed.