Models of β-amyloid induced Tau-pathology: the long and "folded" road to understand the mechanism.
Models of β-amyloid induced Tau-pathology: the long and "folded" road to understand the mechanism.
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DOI：
10.1186/1750-1326-9-51
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发表时间：
2014-11-18
影响因子：
15.1
通讯作者：
Dewachter I
中科院分区：
文献类型：
--
作者：
Stancu IC;Vasconcelos B;Terwel D;Dewachter I
淀粉样蛋白级联假说一直是阿尔茨海默病研究中的主流假说，尽管仍缺乏最后也是最需要的证据，即在患者身上完全成功的抗淀粉样蛋白临床试验。这可能需要对级联有更深入的了解。特别是，A、β和Tau的确切毒性形式、它们之间的分子联系以及它们在疾病过程中各自的贡献需要详细确定。尽管缺乏最终的证据对该假说本身提出了实质性的批评，但在体外模型、体内模型和患者的生物标记物分析中积累的实验证据支持淀粉样级联，特别是β诱导的Tau病理，这是本综述的重点。我们在这里讨论现有的模型，概括Aβ诱导的TAU病理，并回顾一些潜在的潜在机制。这些部分或更完整地模拟淀粉样蛋白级联的模型的可用性和多样性，为研究剩余的问题提供了工具，这些问题对于开发阿尔茨海默病的治疗策略至关重要。本文的在线版本(DOI：10.1186/17501326-9-51)包含补充材料，授权用户可以使用。
The amyloid cascade hypothesis has been the prevailing hypothesis in Alzheimer’s Disease research, although the final and most wanted proof i.e. fully successful anti-amyloid clinical trials in patients, is still lacking. This may require a better in depth understanding of the cascade. Particularly, the exact toxic forms of Aβ and Tau, the molecular link between them and their respective contributions to the disease process need to be identified in detail. Although the lack of final proof has raised substantial criticism on the hypothesis per se, accumulating experimental evidence in in vitro models, in vivo models and from biomarkers analysis in patients supports the amyloid cascade and particularly Aβ-induced Tau-pathology, which is the focus of this review. We here discuss available models that recapitulate Aβ-induced Tau-pathology and review some potential underlying mechanisms. The availability and diversity of these models that mimic the amyloid cascade partially or more complete, provide tools to study remaining questions, which are crucial for development of therapeutic strategies for Alzheimer’s Disease. The online version of this article (doi:10.1186/1750-1326-9-51) contains supplementary material, which is available to authorized users.
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影响因子：
12.7
作者：
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通讯作者：
Del Tredici, Kelly
影响因子：
16.2
作者：
Bhaskar, Kiran;Konerth, Megan;Kokiko-Cochran, Olga N.;Cardona, Astrid;Ransohoff, Richard M.;Lamb, Bruce T.
通讯作者：
Lamb, Bruce T.
影响因子：
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通讯作者：
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作者：
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通讯作者：
Delatour B
影响因子：
64.8
作者：
De Strooper, B;Saftig, P;Van Leuven, F
通讯作者：
Van Leuven, F